Manganese superoxide dismutase in pathogenic fungi:: An issue with pathophysiological and phylogenetic involvements
Manganese superoxide dismutase in pathogenic fungi:: An issue with pathophysiological and phylogenetic involvements
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DOI：
10.1016/j.femsim.2005.06.003
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Delhaes, L
中科院分区：
文献类型：
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作者：
Fréalle, E;Noël, C;Delhaes, L
含锰超氧化物歧化酶（MnSODs）是一种广泛存在的金属酶，参与细胞对内源性和外源性活性氧的防御。在真菌中，使用这种必需的酶进行系统发育分析的肺孢子虫和灵芝属，属，并选择子囊菌门，担子菌门和接合菌门的物种，提供了有趣的结果，在分类和进化。线粒体和胞质MnSOD的作用进行了探讨，在一些致病性担子菌酵母（隐球菌新生变种。Grubii、新型隐球菌变种（Cryptococcus neoformans var.）gattii，合轴马拉色菌（Malassezia sympodialis），子囊菌门丝状真菌（烟曲霉（Aspergillusfumigatus））和子囊菌门酵母（白色念珠菌（Candidaalbicans））。MnSOD为基础的系统发育和致病性的数据面临，以评估真菌MnSOD的病理生理机制中的作用。(c)2005年，欧洲微生物学会联合会。Elsevier B.V.出版，保留所有权利。
Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma, genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.