A prospective study of folate intake and the risk of breast cancer
A prospective study of folate intake and the risk of breast cancer
复制标题
DOI：
10.1001/jama.281.17.1632
复制
发表时间：
1999-05-05
影响因子：
120.7
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Zhang, SM;Hunter, DJ;Willett, WC
背景 叶酸参与 DNA 合成和甲基化，可能降低乳腺癌风险，特别是饮酒较多的女性。目的 评估叶酸摄入量与乳腺癌风险之间的关联，以及较高的叶酸摄入量是否可以降低饮酒女性的过度风险。设计 前瞻性队列研究于 1980 年进行，随访 16 年，设置和参与者 共有 88 818 名女性完成了护士健康研究的饮食问卷部分。 1980.主要结果通过叶酸和酒精摄入水平衡量浸润性乳腺癌的发病率，结果总共记录了 3483 例乳腺癌病例。总叶酸摄入量与乳腺癌的总体风险无关。然而，在每天饮酒至少 15 克的女性中，叶酸摄入量较低的女性患乳腺癌的风险最高。对于至少 600 微克/天的总叶酸摄入量与 150 至 299 微克/天相比，多变量相对风险 (RR) 为 0.55（95% 置信区间 [CI]，0.39-0.76；趋势 P = 0.001）。在对 β 胡萝卜素、叶黄素/玉米黄质、预制维生素 A 以及总维生素 C 和 E 的摄入量进行额外调整后，这种关联仅略有减弱。在叶酸摄入总量低于 300 微克/天的女性中，与酒精摄入相关的乳腺癌风险最强（酒精摄入量大于或等于 15 克/天 vs
Context Folate is involved in DNA synthesis and methylation and may reduce breast cancer risk, particularly among women with greater alcohol consumption.Objectives To assess the association between folate intake and risk of breast cancer and whether higher folate intake may reduce excess risk among women who consume alcohol.Design Prospective cohort study performed in 1980, with 16 years of follow-up,Setting and Participants A total of 88 818 women who completed the dietary questionnaire section of the Nurses' Health Study in 1980.Main Outcome Measure Incidence of invasive breast cancer by levels of folate and alcohol intake,Results A total of 3483 cases of breast cancer were documented. Total folate intake was not associated with overall risk of breast cancer. However, among women who consumed at least 15 g/d of alcohol, the risk of breast cancer was highest among those with low folate intake. For total folate intake of at least 600 mu g/d compared with 150 to 299 mu g/d, the multivariate relative risk (RR) was 0.55 (95% confidence interval [CI], 0.39-0.76; P for trend = .001). This association was only slightly attenuated after additional adjustment for intake of beta carotene, lutein/zeaxanthin, preformed vitamin A, and total vitamins C and E. The risk of breast cancer associated with alcohol intake was strongest among women with total folate intake of less than 300 mu g/d (for alcohol intake greater than or equal to 15 g/d vs