Later circadian timing of food intake is associated with increased body fat
Later circadian timing of food intake is associated with increased body fat
复制标题
DOI：
10.3945/ajcn.117.161588
复制
发表时间：
2017-11-01
影响因子：
7.1
通讯作者：
Klerman, Elizabeth B.
中科院分区：
文献类型：
--
作者：
McHill, Andrew W.;Phillips, Andrew J. K.;Klerman, Elizabeth B.
背景：体重增加和肥胖已经达到了令人担忧的水平。晚些时候进食是一个新描述的不利代谢健康的风险因素;然而，晚些时候进食如何影响身体成分尚不清楚。利用生物钟来记录进食时间可能会产生误导，因为相对于生物钟的生物钟时间存在个体差异。目的：本研究探讨了相对于生物钟的食物消耗时间与内源性生物钟时间、食物摄入量和身体成分之间的关系。设计：我们招募了110名年龄在18-22岁之间的参与者，进行了一项为期30天的横断面研究，记录了他们日常生活中的睡眠和昼夜节律行为。我们使用了一个带有时间戳的图片移动的手机应用程序来记录参与者在日常生活中连续7天的所有食物摄入量，并在实验室评估期间评估他们的身体成分和褪黑激素释放的时间。非瘦个体（高体脂）消耗了他们大部分的热量1.1小时接近褪黑激素发作，这预示着生物之夜的开始，瘦个体（低体脂）（对数秩P = 0.009）。与此相反，有瘦和nonlean个人之间没有差异，在时钟小时的食物消耗（P = 0.72）。多元回归分析显示，相对于褪黑激素起效的进食时间与体脂百分比和体重指数显著相关（均P < 0.05），而进食的时钟时间、热量、膳食常量营养素组成、活动或运动水平之间没有关系，或睡眠时间，以及这些身体成分指标中的任何一个（P均> 0.72）。这些结果提供了证据表明，在昼夜节律的晚上和/或晚上，独立于更传统的风险因素，如食物摄入量或含量和活动水平，在身体组成中起着重要作用。本试验在clinicaltrials.gov上注册为NCT 02846077。
Background: Weight gain and obesity have reached alarming levels. Eating at a later clock hour is a newly described risk factor for adverse metabolic health; yet, how eating at a later circadian time influences body composition is unknown. Using clock hour to document eating times may be misleading owing to individual differences in circadian timing relative to clock hour.Objective: This study examined the relations between the timing of food consumption relative to clock hour and endogenous circadian time, content of food intake, and body composition.Design: We enrolled 110 participants, aged 18-22 y, in a 30-d cross-sectional study to document sleep and circadian behaviors within their regular daily routines. We used a time-stamped-picture mobile phone application to record all food intake across 7 consecutive days during a participant's regular daily routines and assessed their body composition and timing of melatonin release during an in-laboratory assessment.Results: Nonlean individuals (high body fat) consumed most of their calories 1.1 h closer to melatonin onset, which heralds the beginning of the biological night, than did lean individuals (low body fat) (log-rank P = 0.009). In contrast, there were no differences between lean and nonlean individuals in the clock hour of food consumption (P = 0.72). Multiple regression analysis showed that the timing of food intake relative to melatonin onset was significantly associated with the percentage of body fat and body mass index (both P < 0.05) while controlling for sex, whereas no relations were found between the clock hour of food intake, caloric amount, meal macronutrient composition, activity or exercise level, or sleep duration and either of these body composition measures (all P > 0.72).Conclusions: These results provide evidence that the consumption of food during the circadian evening and/or night, independent of more traditional risk factors such as amount or content of food intake and activity level, plays an important role in body composition. This trial was registered at clinicaltrials.gov as NCT02846077.