Increased neurite development and plasminogen activator expression by exposure of human neuroblastoma cells to a plasminogen‐deficient growth medium
Increased neurite development and plasminogen activator expression by exposure of human neuroblastoma cells to a plasminogen‐deficient growth medium
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将人神经母细胞瘤细胞暴露于纤溶酶原缺乏的生长培养基中，增加神经突发育和纤溶酶原激活剂表达
DOI：
10.1002/jcp.1041040108
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发表时间：
1980
影响因子：
5.6
通讯作者：
J. T. Wachsman
中科院分区：
文献类型：
--
作者：
P. Becherer;J. T. Wachsman
人神经母细胞瘤株SK-N-SH在纤溶酶原缺乏的培养液中生长可使分化细胞(突起长度至少50μm的细胞)的数量增加约40%，每个细胞释放的纤溶酶原激活剂的量增加约5倍。纤溶酶原缺乏对SK-N-SH细胞的生长速度没有影响。这些结果与纤溶酶原激活剂参与神经母细胞发育的假设是一致的。
Growth of human neuroblastoma strain SK‐N‐SH in a plasminogen‐deficient medium results in about a 40% increase in the number of differentiated cells (cells with a neurite‐like process at least 50 μm in length) and about a five‐fold increase in the amount of plasminogen activator liberated per cell. Plasminogen deficiency has no effect on the growth rate of SK‐N‐SH cells. These results are consistent with the hypothesis that plasminogen activator is involved in neuroblast development.