Pilot Study of Maternal Autoantibody-Related Autism.
Pilot Study of Maternal Autoantibody-Related Autism.
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DOI：
10.1097/dbp.0000000000001100
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发表时间：
2022-10-01
影响因子：
2.4
通讯作者：
Van de Water, Judy
中科院分区：
文献类型：
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作者：
Angkustsiri, Kathleen;Fussell, Jill J.;Bennett, Amanda;Schauer, Joseph;Ramirez-Celis, Alexandra;Hansen, Robin L.;Van de Water, Judy
关键词：
研究2个地理位置不同的DBPNet临床研究中心（宾夕法尼亚州和阿肯色州）中是否存在母体自身抗体相关自闭症谱系障碍（MAR ASD）。MAR ASD是自闭症谱系障碍的一种生物学定义的亚型，其定义为存在对胎儿脑中蛋白质特异性的自身抗体，并且存在于北方加州样本的约20%中，但尚未在其他州进行研究。从2个DBPNet诊所招募了68名ASD儿童的母亲，并提供了血液样本。母亲们还完成了关于孩子的行为问卷，并从孩子的临床诊断评估中提取了数据。母亲的平均年龄为38.5±6.1岁，儿童的平均年龄为8.3±2.7岁。MAR ASD存在于24%的样本中，并且在各研究中心之间相似。通过ADOS比较评分（W=3604，p<0.001）和社会沟通问卷（W=4556; p<0.001）测量，+MAR母亲的儿童有更严重的自闭症症状。在智商、适应功能或异常行为方面没有差异。MAR ASD是自闭症的一种亚型，在3个州以相似的频率存在，并与自闭症的严重程度有关。
To investigate the presence of Maternal Autoantibody-Related Autism Spectrum Disorder (MAR ASD) in 2 geographically distinct DBPNet clinical sites (Pennsylvania and Arkansas). MAR ASD is a biologically defined subtype of autism spectrum disorder that is defined by the presence of autoantibodies specific to proteins in the fetal brain and present in approximately 20% of a Northern California sample but has not been studied in other states. Sixty-eight mothers of children with ASD were recruited from 2 DBPNet clinics and provided blood samples. Mothers also completed behavioral questionnaires about their children, and data from the child’s clinical diagnostic assessment was abstracted. Mean age of mothers was 38.5±6.1 years, and mean age of children was 8.3±2.7 years. MAR ASD was present in 24% of the sample and similar across sites. Children of +MAR mothers had more severe autism symptoms as measured by ADOS comparison scores (W=3604, p<0.001) and the Social Communication Questionnaire (W=4556; p<0.001). There were no differences in IQ, adaptive function, or aberrant behavior. MAR ASD is a subtype of autism that is present in similar frequencies across 3 states and related to autism severity.