Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings.
Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings.
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DOI：
10.3389/fped.2021.793326
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发表时间：
2021
影响因子：
2.6
通讯作者：
Bhutta AT
中科院分区：
文献类型：
--
作者：
Abbas Q;Holloway A;Caporal P;López-Barón E;Agulnik A;Remy KE;Appiah JA;Attebery J;Fink EL;Lee JH;Hooli S;Kissoon N;Miller E;Murthy S;Muttalib F;Nielsen K;Puerto-Torres M;Rodrigues K;Sakaan F;Rodrigues AT;Tabor EA;von Saint Andre-von Arnim A;Wiens MO;Blackwelder W;He D;Kortz TB;Bhutta AT
资源有限环境（RLS）中儿科危重病的负担和危重病儿童的资源利用在很大程度上是未知的。没有具体的数据，捕捉关键方面的危重病，疾病表现，资源利用的儿科人群在RLS中，适当的，基于证据的干预措施，以指导有限的，但可用的资源分配的背景框架的发展是具有挑战性的。我们提出了这篇方法论文，描述了我们的努力，以确定患病率，病因，医院的结果，和资源利用与儿科急性，危重病在全球RLS。我们将在来自北美、中美和南美、非洲、中东和南亚的61家参与RLS的医院中进行一项前瞻性、观察性、多中心、多国点患病率研究，在12个月期间的4个采样时间点进行。年龄在29天至14岁之间的儿童（在急诊科评估为急性疾病或损伤）或直接入住住院单位的儿童将入组，并在住院的前7天随访医院结局和资源利用。主要结局将是急性危重病的患病率，Global PARITY将其定义为入院后48小时内死亡，包括艾德死亡;或入院/转入HDU或ICU;或转入另一家机构接受更高水平的护理;或接受重症监护级别的干预（血管加压素输注、有创机械通气、无创机械通气），无论在医院的任何位置，在到医院就诊的儿童中。次要结局包括危重病的病因、住院死亡率、死亡原因、资源利用、住院时间和神经认知状态的变化。数据将通过REDCap进行管理，并在各研究中心进行汇总和分析。这项研究有望解决目前在理解RLS中与儿科急危重症相关的负担、病因、资源利用和结局方面的差距。这些数据对于未来的研究和临床管理决策以及改善全球儿科医院的结果至关重要。
The burden of pediatric critical illness and resource utilization by children with critical illness in resource limited settings (RLS) are largely unknown. Without specific data that captures key aspects of critical illness, disease presentation, and resource utilization for pediatric populations in RLS, development of a contextual framework for appropriate, evidence-based interventions to guide allocation of limited but available resources is challenging. We present this methods paper which describes our efforts to determine the prevalence, etiology, hospital outcomes, and resource utilization associated with pediatric acute, critical illness in RLS globally. We will conduct a prospective, observational, multicenter, multinational point prevalence study in sixty-one participating RLS hospitals from North, Central and South America, Africa, Middle East and South Asia with four sampling time points over a 12-month period. Children aged 29 days to 14 years evaluated for acute illness or injury in an emergency department) or directly admitted to an inpatient unit will be enrolled and followed for hospital outcomes and resource utilization for the first seven days of hospitalization. The primary outcome will be prevalence of acute critical illness, which Global PARITY has defined as death within 48 hours of presentation to the hospital, including ED mortality; or admission/transfer to an HDU or ICU; or transfer to another institution for a higher level-of-care; or receiving critical care-level interventions (vasopressor infusion, invasive mechanical ventilation, non-invasive mechanical ventilation) regardless of location in the hospital, among children presenting to the hospital. Secondary outcomes include etiology of critical illness, in-hospital mortality, cause of death, resource utilization, length of hospital stay, and change in neurocognitive status. Data will be managed via REDCap, aggregated, and analyzed across sites. This study is expected to address the current gap in understanding of the burden, etiology, resource utilization and outcomes associated with pediatric acute and critical illness in RLS. These data are crucial to inform future research and clinical management decisions and to improve global pediatric hospital outcomes.
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影响因子：
168.9
作者：
Bhutta, Zulfiqar A.;Das, Jai K.;Black, Robert E.
通讯作者：
Black, Robert E.
影响因子：
158.5
作者：
Maitland, Kathryn;Kiguli, Sarah;Gibb, Diana M.
通讯作者：
Gibb, Diana M.
影响因子：
168.9
作者：
Liu, Li;Oza, Shefali;Hogan, Dan;Chu, Yue;Perin, Jamie;Zhu, Jun;Lawn, Joy E.;Cousens, Simon;Mathers, Colin;Black, Robert E.
通讯作者：
Black, Robert E.
影响因子：
2.6
作者：
von Saint André-von Arnim AO;Attebery J;Kortz TB;Kissoon N;Molyneux EM;Musa NL;Nielsen KR;Fink EL;Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
通讯作者：
Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
影响因子：
26.1
作者：
Global Burden of Disease Child and Adolescent Health Collaboration;Kassebaum N;Kyu HH;Zoeckler L;Olsen HE;Thomas K;Pinho C;Bhutta ZA;Dandona L;Ferrari A;Ghiwot TT;Hay SI;Kinfu Y;Liang X;Lopez A;Malta DC;Mokdad AH;Naghavi M;Patton GC;Salomon J;Sartorius B;Topor-Madry R;Vollset SE;Werdecker A;Whiteford HA;Abate KH;Abbas K;Damtew SA;Ahmed MB;Akseer N;Al-Raddadi R;Alemayohu MA;Altirkawi K;Abajobir AA;Amare AT;Antonio CAT;Arnlov J;Artaman A;Asayesh H;Avokpaho EFGA;Awasthi A;Ayala Quintanilla BP;Bacha U;Betsu BD;Barac A;Bärnighausen TW;Baye E;Bedi N;Bensenor IM;Berhane A;Bernabe E;Bernal OA;Beyene AS;Biadgilign S;Bikbov B;Boyce CA;Brazinova A;Hailu GB;Carter A;Castañeda-Orjuela CA;Catalá-López F;Charlson FJ;Chitheer AA;Choi JJ;Ciobanu LG;Crump J;Dandona R;Dellavalle RP;Deribew A;deVeber G;Dicker D;Ding EL;Dubey M;Endries AY;Erskine HE;Faraon EJA;Faro A;Farzadfar F;Fernandes JC;Fijabi DO;Fitzmaurice C;Fleming TD;Flor LS;Foreman KJ;Franklin RC;Fraser MS;Frostad JJ;Fullman N;Gebregergs GB;Gebru AA;Geleijnse JM;Gibney KB;Gidey Yihdego M;Ginawi IAM;Gishu MD;Gizachew TA;Glaser E;Gold AL;Goldberg E;Gona P;Goto A;Gugnani HC;Jiang G;Gupta R;Tesfay FH;Hankey GJ;Havmoeller R;Hijar M;Horino M;Hosgood HD;Hu G;Jacobsen KH;Jakovljevic MB;Jayaraman SP;Jha V;Jibat T;Johnson CO;Jonas J;Kasaeian A;Kawakami N;Keiyoro PN;Khalil I;Khang YH;Khubchandani J;Ahmad Kiadaliri AA;Kieling C;Kim D;Kissoon N;Knibbs LD;Koyanagi A;Krohn KJ;Kuate Defo B;Kucuk Bicer B;Kulikoff R;Kumar GA;Lal DK;Lam HY;Larson HJ;Larsson A;Laryea DO;Leung J;Lim SS;Lo LT;Lo WD;Looker KJ;Lotufo PA;Magdy Abd El Razek H;Malekzadeh R;Markos Shifti D;Mazidi M;Meaney PA;Meles KG;Memiah P;Mendoza W;Abera Mengistie M;Mengistu GW;Mensah GA;Miller TR;Mock C;Mohammadi A;Mohammed S;Monasta L;Mueller U;Nagata C;Naheed A;Nguyen G;Nguyen QL;Nsoesie E;Oh IH;Okoro A;Olusanya JO;Olusanya BO;Ortiz A;Paudel D;Pereira DM;Perico N;Petzold M;Phillips MR;Polanczyk GV;Pourmalek F;Qorbani M;Rafay A;Rahimi-Movaghar V;Rahman M;Rai RK;Ram U;Rankin Z;Remuzzi G;Renzaho AMN;Roba HS;Rojas-Rueda D;Ronfani L;Sagar R;Sanabria JR;Kedir Mohammed MS;Santos IS;Satpathy M;Sawhney M;Schöttker B;Schwebel DC;Scott JG;Sepanlou SG;Shaheen A;Shaikh MA;She J;Shiri R;Shiue I;Sigfusdottir ID;Singh J;Silpakit N;Smith A;Sreeramareddy C;Stanaway JD;Stein DJ;Steiner C;Sufiyan MB;Swaminathan S;Tabarés-Seisdedos R;Tabb KM;Tadese F;Tavakkoli M;Taye B;Teeple S;Tegegne TK;Temam Shifa G;Terkawi AS;Thomas B;Thomson AJ;Tobe-Gai R;Tonelli M;Tran BX;Troeger C;Ukwaja KN;Uthman O;Vasankari T;Venketasubramanian N;Vlassov VV;Weiderpass E;Weintraub R;Gebrehiwot SW;Westerman R;Williams HC;Wolfe CDA;Woodbrook R;Yano Y;Yonemoto N;Yoon SJ;Younis MZ;Yu C;Zaki MES;Zegeye EA;Zuhlke LJ;Murray CJL;Vos T
通讯作者：
Vos T