Quantifying tonal loss after optic neuritis with optical coherence tomography
Quantifying tonal loss after optic neuritis with optical coherence tomography
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DOI：
10.1002/ana.20851
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发表时间：
2006-06-01
影响因子：
11.2
通讯作者：
Kardon, RH
中科院分区：
文献类型：
--
作者：
Costello, F;Coupland, S;Kardon, RH
目的：为了确定什么程度的变化，在视网膜神经纤维层（RNFL）的厚度后视神经炎（ON）与视力恢复或impairment.Methods：ON可以导致可见的缺陷内的RNFL，这可以量化使用光学相干断层扫描（OCT）。通过测量ON后RNFL的损失来预测视力恢复是可能的。54例患者在ON后接受了光学相干断层扫描和标准化眼科测试的重复评估。回归分析用于确定RNFL厚度与视功能之间的关系。大多数患者（74%）的RNFL变薄，患眼的平均RNFL值（78 μ m）比未患眼（100 μ m）薄（p < 0.0001）。视力恢复不完全的患者表现出更大的RNFL损失后ON.Regression分析表明，阈值的RNFL厚度（75 μ m），低于该RNFL测量预测持续的视觉dysfunction.Interpretation：RNFL厚度的测定可以预测视力恢复后ON，和较低的RNFL值与受损的视觉功能。光学相干断层扫描可能有一个潜在的作用，作为一个替代标记的轴突完整性的视神经患者之间的ON。
Objective: To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness after optic neuritis (ON) correlate with either visual recovery or impairment.Methods: ON can cause visible defects within the RNFL, which can be quantified using optical coherence tomography (OCT). It may be possible to predict visual recovery by measuring RNFL loss after ON. Fifty-four patients underwent repeated evaluations with optical coherence tomography and standardized ophthalmic testing after ON. Regression analyses were used to determine the relationship between RNFL thickness and visual function.Results: Thinning of the RNFL was seen in the majority of patients (74%), and it tended to occur within 3 to 6 months of ON. The average RNFL value was thinner (p < 0.0001) in the affected (78 mu m) compared with the unaffected eye (100 mu m). Patients with incomplete visual recovery demonstrated greater RNFL loss after ON. Regression analyses demonstrated a threshold of RNFL thickness (75 mu m), below which RNFL measurements predicted persistent visual dysfunction.Interpretation: Determination of RNFL thickness may predict visual recovery after ON, and lower RNFL values correlate with impaired visual function. Optical coherence tomography may have a potential role as a surrogate marker for axonal integrity within the optic nerve among patients with ON.