Adjuvant treatment ant onset of menopause predict weight gain after breast cancer diagnosis
Adjuvant treatment ant onset of menopause predict weight gain after breast cancer diagnosis
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DOI：
10.1200/jco.1999.17.1.120
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发表时间：
1999-01-01
影响因子：
45.3
通讯作者：
Redwood, S
中科院分区：
文献类型：
--
作者：
Goodwin, PJ;Ennis, M;Redwood, S
目的：乳腺癌诊断后第一年体重增加很常见。在这项研究中，我们检查了与体重、诊断和随后一年体重增加相关的临床因素。 患者和方法：由 535 名新诊断局部乳腺癌女性组成的初始队列在基线和一年内接受了人体测量。收集有关肿瘤和治疗相关变量以及饮食和体力活动的信息。结果：平均年龄为 50.3 岁； 57%的女性处于绝经前。平均基线体重指数（体重[kg]除以身高[m]的平方）为25.5 kg/m(2)。总体而言，84.1%的患者体重增加。接受化疗的患者平均体重增加为 1.6 公斤（95% 置信区间，1.2 至 1.9 公斤）、2.5 公斤（95% 置信区间，1.8 至 3.2 公斤），仅接受他莫昔芬治疗的患者平均体重增加 1.3 公斤（95% 置信区间，0.7 至 1.8 公斤），未接受化疗的患者平均体重增加 0.6 公斤（95% 置信区间，0.01 至 1.3 公斤）。单变量分析中，辅助治疗、诊断时绝经状态 (P = .02)、随后一年绝经状态的变化 (P = .002)、腋窝淋巴结状态 (P = .009) 和辅助治疗 (P = .0002) 预测体重增加。在多变量分析中，绝经开始和化疗是诊断后一年内体重增加（所有 P 小于或等于 0.05）、热量摄入减少（P < .01）和体力活动增加（P < .05）的独立预测因素；这些因素并不能解释观察到的体重增加。结论：乳腺癌诊断后体重增加很常见；辅助化疗的使用和绝经的开始是这种体重增加的最强的临床预测因子。J Clin Oncol 17:120-129，(C) 1999，美国临床肿瘤学会。
Purpose: Weight gain is common during the first year after breast cancer diagnosis. in this study, we examined clinical factors associated with body size a, diagnosis and weight gain during the subsequent year.Patients and Methods: An inception cohort of 535 women with newly diagnosed locoregional breast cancer underwent anthropometric measurements at baseline and 1 year. information was collected on tumor and treatment-related variables, as well as diet and physical activity.Results: Mean age was 50.3 years; 57% of women were premenopausal. Mean baseline body mass index (weight [kg] divided by height [m] squared) was 25.5 kg/m(2). Overall, 84.1% of the patients gained weight. Mean weight gain was 1.6 kg (95% confidence interval, 1.2 to 1.9 kg), 2.5 kg (95% confidence interval, 1.8 to 3.2 kg) in those receiving chemotherapy, 1.3 kg (95% confidence interval, 0.7 to 1.8 kg) in those receiving tamoxifen only and 0.6 kg (95% confidence interval, 0.01 to 1.3 kg) in those receiving no adjuvant treatment, Menopausal status at diagnosis (P = .02), change in menopausal status over the subsequent year (P = .002), axillary nodal status (P = .009), and adjuvant treatment (P = .0002) predicted weight gain in univariate analysis. In multivariate analysis, onset of menopause and administration of chemotherapy were independent predictors of weight gain (all P less than or equal to .05), Caloric intake decreased (P < .01) and physical activity increased (P < .05) during the year after diagnosis; these factors did not explain the observed weighs gain,Conclusion: Weighs gain is common after breast cancer diagnosis; use of adjuvant chemotherapy and onset of menopause are the strongest clinical predictors of this weight gain.J Clin Oncol 17:120-129, (C) 1999 by American Society of Clinical Oncology.