Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche
Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche
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DOI：
10.1016/j.trsl.2007.09.003
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发表时间：
2008-01-01
影响因子：
7.8
通讯作者：
Sipkins, Dorothy A.
中科院分区：
文献类型：
--
作者：
Colmone, Angela;Sipkins, Dorothy A.
特定的组织微环境或生态位对于干细胞和肿瘤细胞在体内的归巢和维持至关重要。然而，人们对这些微环境中单个细胞之间的分子相互作用知之甚少。最近的研究描述了骨髓中新发现的造血干细胞和肿瘤细胞血管生态位（BM），表明血管内皮细胞信号传导的关键作用，并提出了这些细胞与血管系统的双向相互作用动态调节生态位的可能性。造血干细胞/肿瘤细胞与内皮细胞串扰的机制为今后的研究提供了一个有希望的新方向。在这里，我们回顾了在这一领域开辟新的研究途径的最新进展。[j] .翻译研究（英文版）；
Specific tissue microenvironments, or niches, are critical for homing and maintenance of both stem cells and tumor cells in vivo. Little is known, however, about the molecular interactions between individual cells within these microenvironments. Recent studies that describe a newly identified hematopoietic stem and tumor cell vascular niche in the bone marrow (BM) suggest a critical role for vascular endothelial cell signaling and raise the possibility that bidirectional interactions of these cells with the vasculature regulate the niche dynamically. The mechanisms that govern hematopoietic stem cell (HSC)/tumor cell cross-talk with endothelial cells provide a promising new direction for future studies. Here we review recent advances that open new avenues of study in this field. (Translational Research 2008; 151:1-9).