Tracing insights into human metabolism using chemical engineering approaches.
Tracing insights into human metabolism using chemical engineering approaches.
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DOI：
10.1016/j.coche.2016.08.019
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发表时间：
2016-11
影响因子：
6.6
通讯作者：
Metallo CM
中科院分区：
文献类型：
--
作者：
Cordes T;Metallo CM
代谢协调可利用营养物向能量、生物合成中间体和信号分子的转化，以介导几乎所有的生物功能。代谢途径的失调导致许多疾病，因此对人体代谢的详细了解具有重要的治疗意义。在过去的十年中，分析化学、细胞内通量的计算估计和生物工程领域的主要技术进步提高了我们观察和设计代谢途径的能力。这些方法让人想起工业化工厂的设计、操作和控制。免疫细胞已经成为一个有趣的系统，其中代谢影响各种生物功能。代谢通量分析和相关方法在巨噬细胞和T细胞中的应用为生化工程师提供了巨大的治疗机会。
Metabolism coordinates the conversion of available nutrients toward energy, biosynthetic intermediates, and signaling molecules to mediate virtually all biological functions. Dysregulation of metabolic pathways contributes to many diseases, so a detailed understanding of human metabolism has significant therapeutic implications. Over the last decade major technological advances in the areas of analytical chemistry, computational estimation of intracellular fluxes, and biological engineering have improved our ability to observe and engineer metabolic pathways. These approaches are reminiscent of the design, operation, and control of industrial chemical plants. Immune cells have emerged as an intriguing system in which metabolism influences diverse biological functions. Application of metabolic flux analysis and related approaches to macrophages and T cells offers great therapeutic opportunities to biochemical engineers.