Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit.
Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit.
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乙酰甘油醚磷酸胆碱（兔子 IgE 过敏反应的介体）诱导的呼吸和循环改变。
DOI：
10.1164/arrd.1980.122.6.915
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Pinckard,RN
中科院分区：
文献类型：
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作者：
Halonen,M;Palmer,JD;Lohman,IC;McManus,LM;Pinckard,RN
我们检测了乙酰甘油醚磷酸胆碱（AGEPC）在兔体内引起的生理变化，这是一种与兔嗜碱性粒细胞衍生的血小板活化因子相同的合成化合物。静脉给药AGEPC导致短时间快速浅呼吸，一过性呼吸暂停，动态顺应性降低，总肺阻力增加。循环改变包括短暂的心动过缓、右心室压升高和全身性低血压。当剂量为0.6µg/kg时，AGEPC产生的生理改变在定性和定量上与兔的IgE过敏反应特征难以区分。死亡率也相似。在恢复到挑战前基线值后，随后的AGEPC剂量导致许多生理改变的减弱反应。血小板减少、白细胞减少和血小板分泌（通过血小板因子4释放到血浆中来评估）也是AGEPC反应的一部分，进一步延长了这种反应与IgE过敏反应的相似性。由于AGEPC先前已被证明在IgE过敏反应期间释放到循环中，我们的结果提供了强有力的证据，证明AGEPC是兔这种急性过敏反应的重要介质。
We examined the physiologic alterations induced in the rabbit by an acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic compound identical to rabbit basophil-derived platelet-activating factor. Intravenous administration of AGEPC led to a brief period of rapid, shallow breathing, a transient apnea, a decrease in dynamic compliance, and an increase in total pulmonary resistance. Circulatory alterations included brief bradycardia, increase in right ventricular pressure, and systemic hypotension. At a dose of 0.6 µg/kg, AGEPC produced physiologic alterations both qualitatively and quantitatively indistinguishable from those which characterize IgE anaphylaxis in the rabbit. Mortality was also similar. After recovery to prechallenge baseline values, subsequent doses of AGEPC resulted in attenuated responses with respect to many of the physiologic alterations. Thrombocytopenia, leukopenia, and platelet secretion (as assessed by release of platelet factor 4 into the plasma) were also part of the response to AGEPC, further extending the similarity of this response to IgE anaphylaxis. Because AGEPC has been shown previously to be released into the circulation during IgE anaphylaxis, our results provide strong evidence that AGEPC is an important mediator of this acute allergic reaction in the rabbit.