Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT

Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT
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DOI:
10.1016/j.nec.2012.01.011
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发表时间:
2012-04-01
影响因子:
2.6
通讯作者:
Li, Gordon
Li, Gordon
中科院分区:
医学3区
文献类型:
--
作者:
Camara-Quintana, Joaquin Q.;Nitta, Ryan T.;Li, Gordon

文献摘要

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本文的目的是更新神经外科领域对胶质母细胞瘤生物学、治疗和预后重要的当前分子标记。本文重点介绍的生物标志物包括表皮生长因子受体(EGFR)、表皮生长因子受体变体ii (EGFRvIII)、10号染色体上缺失的磷酸酶和张力素同源物(PTEN)以及o6 -甲基鸟嘌呤- dna甲基转移酶(MGMT)。
The purpose of this article is to update the neurosurgical field on current molecular markers important to glioblastoma biology, treatment, and prognosis. The highlighted biologic markers in this article include epidermal growth factor receptor (EGFR), EGFR variant Ill (EGFRvIII), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and O6-methylguanine-DNA methyltransferase (MGMT).