Kinetics of rabies antibodies as a strategy for canine active immunization
Kinetics of rabies antibodies as a strategy for canine active immunization
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DOI：
10.1186/1678-9199-20-37
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发表时间：
2014-01-01
影响因子：
2.4
通讯作者：
Modolo, José Rafael
中科院分区：
文献类型：
--
作者：
Babboni, Selene Daniela;Costa, Hení Falcão da;Modolo, José Rafael
背景：狂犬病是一种在全球范围内发现的人畜共患病，由一种溶沙氏病毒属病毒引起。这种疾病通过接种感染哺乳动物唾液中的病毒传播给人类。由于狂犬病的预后通常对人类是致命的，全国范围内为狗和猫接种狂犬病疫苗的公共运动旨在打破狂犬病病毒与巴西宿主之间的流行病学联系。结果：在12个月的时间里，我们在巴西圣帕乌特州博图卡图市城区评估了首次接种狂犬病疫苗(在第一次接种后30天接种加强疫苗)的狗的主动免疫力。在被分析的狗中，54.7%的狗在第一次接种后360天内保持保护性滴度(~gt；=0.5IU/mL)，而在整个研究期间，51.5%的狗保持了保护效价。结论：本研究结果为从未接种过疫苗的狗提供了一种新的接种计划。除了第一剂疫苗外，还建议再接种两剂：第一剂疫苗后30天接种第二剂疫苗，第一剂疫苗后180天接种第三剂疫苗，以在12个月内维持保护性滴度。
Background: Rabies, a zoonosis found throughout the globe, is caused by a virus of the Lyssavirus genus. The disease is transmitted to humans through the inoculation of the virus present in the saliva of infected mammals. Since its prognosis is usually fatal for humans, nationwide public campaigns to vaccinate dogs and cats against rabies aim to break the epidemiological link between the virus and its reservoirs in Brazil.Findings: During 12 months we evaluated the active immunity of dogs first vaccinated (booster shot at 30 days after first vaccination) against rabies using the Fuenzalida-Palacios modified vaccine in the urban area of Botucatu city, Sao Pauto state, Brazil. Of the analyzed dogs, 54.7% maintained protective titers (>= 0.5 IU/mL) for 360 days after the first vaccination whereas 51.5% during all the study period.Conclusions: The present results suggest a new vaccination schedule for dogs that have never been vaccinated. In addition to the first dose of vaccine, two others are recommended: the second at 30 days after the first and the third dose at 180 days after the first for the maintenance of protective titers during 12 months.