Regional homogeneity of the resting-state brain activity correlates with individual intelligence
Regional homogeneity of the resting-state brain activity correlates with individual intelligence
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DOI：
10.1016/j.neulet.2010.11.046
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发表时间：
2011-01
影响因子：
2.5
通讯作者：
Leiqiong Wang;Ming Song;T. Jiang;Yunting Zhang;Chunshui Yu
中科院分区：
文献类型：
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作者：
Leiqiong Wang;Ming Song;T. Jiang;Yunting Zhang;Chunshui Yu
静息态功能磁共振成像已经证实，不同脑区之间的长距离功能连接的强度与智力的个体差异相关。然而，特定大脑区域内的局部连接与休息时的智力之间的关联在很大程度上仍然未知。本研究的目的是探讨本地连接和智力之间的关系。59名右利手的健康成年人参与了这项研究。区域同质性（ReHo）被用来评估本地连接的强度。ReHo和全量表智商（FSIQ）分数之间的关联进行了研究，在体素明智的方式使用偏相关分析控制的年龄和性别。FSIQ评分与双侧顶下小叶、额中回、海马旁回、颞下回、右侧丘脑、上级回、梭状回、左侧上级顶叶的ReHo值呈正相关。主要发现与智力的顶叶-额叶整合理论（P-FIT）一致，支持一般智力涉及整个大脑的多个大脑区域的观点。
Resting-state functional magnetic resonance imaging has confirmed that the strengths of the long distance functional connectivity between different brain areas are correlated with individual differences in intelligence. However, the association between the local connectivity within a specific brain region and intelligence during rest remains largely unknown. The aim of this study is to investigate the relationship between local connectivity and intelligence. Fifty-nine right-handed healthy adults participated in the study. The regional homogeneity (ReHo) was used to assess the strength of local connectivity. The associations between ReHo and full-scale intelligence quotient (FSIQ) scores were studied in a voxel-wise manner using partial correlation analysis controlling for age and sex. We found that the FSIQ scores were positively correlated with the ReHo values of the bilateral inferior parietal lobules, middle frontal, parahippocampal and inferior temporal gyri, the right thalamus, superior frontal and fusiform gyri, and the left superior parietal lobule. The main findings are consistent with the parieto-frontal integration theory (P-FIT) of intelligence, supporting the view that general intelligence involves multiple brain regions throughout the brain.