Parvalbumin-containing neurons in the basal forebrain receive direct input from the substantia nigra-ventral tegmental area
Parvalbumin-containing neurons in the basal forebrain receive direct input from the substantia nigra-ventral tegmental area
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DOI：
10.1016/s0006-8993(96)01309-1
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发表时间：
1997-01-30
期刊：
影响因子：
2.9
通讯作者：
Zaborszky, L
中科院分区：
文献类型：
--
作者：
Gaykema, RPA;Zaborszky, L
通过对寻常Phaseolus -白细胞凝集素（PHA-L）的顺行示踪，确定了基底前脑的小白蛋白免疫反应神经元是否接受来自黑质和腹侧被盖区A9-A10多巴胺能核的直接突触输入。对前脑切片进行光镜和电镜下PHA-L和小白蛋白（PV）的免疫细胞化学检测。在超微结构水平上，发现pha -l标记的终末与腹内侧苍白球、腹侧苍白球、内囊和无名质的pv免疫反应神经元体建立突触接触。因此，姑息侧和邻近基底前脑区域的pv -含神经元可能是A9-A10多巴胺能神经元的直接靶向，代表了中脑多巴胺能控制基底前脑神经元活动的一个新方面。
By means of anterograde tracing of Phaseolus vulgaris-leucoagglutinin (PHA-L) it was determined if parvalbumin-immunoreactive neurons in the basal forebrain receive a direct synaptic input from the A9-A10 dopaminergic nuclei of the substantia nigra and ventral tegmental area. Forebrain sections were processed for immunocytochemical detection of PHA-L and parvalbumin (PV) at light and electron microscopic levels. At the ultrastructural level, PHA-L-labeled terminals were found to establish synaptic contacts with PV-immunoreactive neuronal somata in the ventromedial globus pallidus, the ventral pallidum, the internal capsule, and the substantia innominata. PV-containing neurons in pallidal and adjacent basal forebrain territories are thus directly targeted by presumably A9-A10 dopaminergic neurons and represent a novel aspect of midbrain dopaminergic control of basal forebrain neuronal activity.