Effect of variations in pressure and flow on the geometry of isolated canine carotid arteries.
Effect of variations in pressure and flow on the geometry of isolated canine carotid arteries.
复制标题
压力和流量变化对离体犬颈动脉几何形状的影响。
DOI：
10.1016/0021-9290(87)90143-6
复制
发表时间：
1987
影响因子：
2.4
通讯作者：
Borovetz,HS
中科院分区：
文献类型：
--
作者：
Brant,AM;Teodori,MF;Kormos,RL;Borovetz,HS
描述了一项体外研究血流动力学对动脉几何形状的影响的研究。一种新的灌注仪被用来在严格控制的条件下通过离体犬颈动脉输送搏动性血流。灌流血管直径和动脉壁厚度的数据来自脉动血管的径向位移，用扫描激光测微仪测量，其精度被确定为0.0125毫米(0.0005英寸)。30个灌流实验的结果表明，跨壁压、脉压和流速等血流动力学变量影响血管大小和径向应变。对这些发现的生理学意义进行了讨论。
A study is described in which the effects of hemodynamics on arterial geometry are investigatedin vitro. A novel perfusion apparatus is employed to deliver pulsatile flow through excised canine carotid arteries under carefully controlled conditions. Data of perfused vessel diameter and arterial wall thickness are derived from the radial displacement of the pulsating vessel as measured using a scanning laser micrometer whose accuracy is determined to be 0.0125 mm (0.0005 in). The results of 30 perfusion experiments suggest that the hemodynamic variables of transmural pressure, pulse pressure and flow rate influence vessel size and radial strain. The physiologic implications of these findings are discussed.