The development of the lung in mammals: an analysis of concepts and findings.

The development of the lung in mammals: an analysis of concepts and findings.
复制标题

哺乳动物肺部的发育：概念和发现的分析。

DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
A. T. Have
A. T. Have
中科院分区：
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文献类型：
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作者：
A. T. Have

文献摘要

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为了评价一种哺乳动物肺发育的分期模型，将CPB-S小鼠品系的产前和产后肺发育分为目前区分的两个阶段：假腺期，包括空气传导部分的建立；以及小管期，末囊期，肺泡期或产后期，在此期间呼吸部分发育。最后三个时期分别包括呼吸单位或肺腺泡（肺腺泡）的不同组成部分（非肺泡性呼吸细支气管、非肺泡性导管和囊、肺泡袋）的形成。然而，根据最近有关上皮的发现确定相关结构的性质表明，这些假设是站不住脚的。由于具有立方上皮的小管（出现在假腺期及以后的时期）是肺腺泡发生的基本结构，因此呼吸部分的发育必须从假腺期开始。同样，由于腺泡的决定性成分来源于这个腺泡小管，它们的建立可能不限于其他时期之一。
To evaluate one model of mammalian-lung development, i.e., division into periods, pre- and postnatal lung development in the CPB-S mouse strain was divided into the currently distinguished periods: the pseudoglandular period, covering establishment of the air-conducting portion; and the canalicular, terminal-sac, and alveolar or postnatal periods, in which the respiratory portion develops. The last three periods would each cover the formation of a different component of the respiratory unit or pulmonary acinus (acinus pulmonaris) (nonalveolated respiratory bronchiole, nonalveolated duct and sac, and alveolar pouch). However, determination of the nature of the relevant structures on the basis of recent findings concerning the epithelia showed that these hypotheses are not tenable. Since the tubule with cuboidal epithelium (appearing in the pseudoglandular and following periods) is the basic structure in the genesis of the pulmonary acinus, the development of the respiratory portion must start in the pseudoglandular period. Likewise, since the definitive components of the acinus are derived from this acinar tubule, their establishment may not be restricted to one of the other periods. Because other postulated divisions of mammalian-lung development were based on similar histological interpretations, they cannot reflect the course of mouse-lung development either. Therefore, a developmental scheme based on the recent findings concerning the epithelia is given as well as a tentative scheme for the human lung. The respiratory portion proved to develop by budding of acinar tubules, the mode of budding being not restricted to any particular pattern.