Long non-coding RNAs in the failing heart and vasculature.
Long non-coding RNAs in the failing heart and vasculature.
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DOI：
10.1016/j.ncrna.2018.04.002
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发表时间：
2018-09
影响因子：
5
通讯作者：
Schroen B
中科院分区：
文献类型：
--
作者：
Hermans-Beijnsberger S;van Bilsen M;Schroen B
人类基因组完成后，我们发现我们的大部分 DNA 都被转录为非编码 RNA (ncRNA)，而不是编码蛋白质的信使 RNA。破译这些 ncRNA（包括小 ncRNA 和长 ncRNA (lncRNA)）的功能是一个新兴的研究领域。 LncRNA 与许多疾病有关，其中一些已被确定为疾病发生和进展的关键调节因子，包括心血管疾病 (CVD)。 CVD 每年导致全世界数百万人死亡。危险因素包括冠状动脉疾病、高血压和衰老。在这篇综述中，我们将重点关注 lncRNA 在 CVD 发展的细胞和分子过程中的作用：心肌细胞肥大、纤维化、炎症、血管疾病和衰老。最后，我们讨论了 lncRNA 的生物标志物和治疗潜力。
Following completion of the human genome, it became evident that the majority of our DNA is transcribed into non-coding RNAs (ncRNAs) instead of protein-coding messenger RNA. Deciphering the function of these ncRNAs, including both small- and long ncRNAs (lncRNAs), is an emerging field of research. LncRNAs have been associated with many disorders and a number have been identified as key regulators in the development and progression of disease, including cardiovascular disease (CVD). CVD causes millions of deaths worldwide, annually. Risk factors include coronary artery disease, high blood pressure and ageing. In this review, we will focus on the roles of lncRNAs in the cellular and molecular processes that underlie the development of CVD: cardiomyocyte hypertrophy, fibrosis, inflammation, vascular disease and ageing. Finally, we discuss the biomarker and therapeutic potential of lncRNAs.