RNA-mediated regulation in Gram-positive pathogens: an overview punctuated with examples from the group A Streptococcus.
RNA-mediated regulation in Gram-positive pathogens: an overview punctuated with examples from the group A Streptococcus.
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DOI：
10.1111/mmi.12742
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发表时间：
2014-10
影响因子：
3.6
通讯作者：
Sumby P
中科院分区：
文献类型：
--
作者：
Miller EW;Cao TN;Pflughoeft KJ;Sumby P
基于rna的调控机制代表了一类普遍存在的调控机制，这些调控机制与多种过程相关，包括营养感知、应激反应、水平基因转移调节和毒力因子表达。虽然在革兰氏阴性菌中得到了更好的研究，但文献中充满了rna介导的调节机制对革兰氏阳性菌的毒力和适应性的重要性的例子。调节性RNA分为顺式作用的（如调节共转录RNA的转录、翻译或稳定性的核糖开关）和反式作用的（如靶向分离mrna或蛋白质的小调节RNA）。A群链球菌（GAS，化脓性链球菌）是一种革兰氏阳性细菌病原体，其几种调节RNA机制已被表征。对GAS中rna介导的调控的研究揭示了关于小调控rna如何积极调节靶mRNA稳定性以及CRISPR rna如何从更长的前体加工的新概念。本文综述了革兰氏阳性菌中rna介导的调控，并重点介绍了GAS研究的具体例子。讨论了这些系统在调节细菌毒力方面的关键作用，并概述了未来的前景。
RNA-based mechanisms of regulation represent a ubiquitous class of regulators that are associated with diverse processes including nutrient sensing, stress response, modulation of horizontal gene transfer, and virulence factor expression. While better studied in Gram-negative bacteria, the literature is replete with examples of the importance of RNA-mediated regulatory mechanisms to the virulence and fitness of Gram-positives. Regulatory RNAs are classified as cis-acting, e.g. riboswitches, which modulate the transcription, translation, or stability of co-transcribed RNA, or trans-acting, e.g. small regulatory RNAs, which target separate mRNAs or proteins. The group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive bacterial pathogen from which several regulatory RNA mechanisms have been characterized. The study of RNA-mediated regulation in GAS has uncovered novel concepts with respect to how small regulatory RNAs may positively regulate target mRNA stability, and to how CRISPR RNAs are processed from longer precursors. This review provides an overview of RNA-mediated regulation in Gram-positive bacteria, and is highlighted with specific examples from GAS research. The key roles that these systems play in regulating bacterial virulence are discussed and future perspectives outlined.
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影响因子：
14.9
作者：
Fozo EM;Makarova KS;Shabalina SA;Yutin N;Koonin EV;Storz G
通讯作者：
Storz G
通过反式编码的小 RNA 和宿主因子 RNase III 进行 CRISPR RNA 成熟。
影响因子：
64.8
作者：
Deltcheva, Elitza;Chylinski, Krzysztof;Sharma, Cynthia M.;Gonzales, Karine;Chao, Yanjie;Pirzada, Zaid A.;Eckert, Maria R.;Vogel, Joerg;Charpentier, Emmanuelle
通讯作者：
Charpentier, Emmanuelle
DOI：
10.1126/science.1159689
发表时间：
2008-08-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Brouns SJ;Jore MM;Lundgren M;Westra ER;Slijkhuis RJ;Snijders AP;Dickman MJ;Makarova KS;Koonin EV;van der Oost J
通讯作者：
van der Oost J
影响因子：
10.5
作者：
Boisset, Sandrine;Geissmann, Thomas;Romby, Pascale
通讯作者：
Romby, Pascale
影响因子：
2.8
作者：
Bolotin, A;Ouinquis, B;Ehrlich, SD
通讯作者：
Ehrlich, SD