Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population
Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population
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中国人群TAB2基因多态性与上皮性卵巢癌的关联
DOI：
10.1155/2019/8012979
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发表时间：
2019-08-14
期刊：
影响因子：
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通讯作者：
Wang, Wei
中科院分区：
文献类型：
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作者：
Huang, Xingming;Shen, Can;Wang, Wei
背景资料。卵巢上皮癌(EOC)在世界范围内具有高度的致命性。炎症因子和激素相关信号通路在上皮性卵巢癌的发生中起着重要作用。转化生长因子-β-(转化生长因子-β)激活的蛋白1(MAP3K7)结合蛋白2(TAB2)可能参与卵巢癌的发生。本研究旨在探讨TAB2基因多态性与卵巢上皮性癌的关系。方法：研究方法。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术，对221例患者和252例健康对照的TAB2基因3个单核苷酸多态性(rs237028、rs521845和rs652921)进行了基因分型。SNPs与临床特征之间的关联通过CHI(2)检验或Fisher‘s精确检验进行。采用Kaplan-Meier方法和Cox比例风险模型检测基因分型与总存活率之间的关系。结果。等位基因遗传模式(A vs.G；OR=1.45；95%CI=1.07-1.96；P=0.016)、显性遗传模式(AA vs.AG-GG；OR=1.66；CI1.14-2.41；P=0.008)和超显性遗传模式(AA-GG vs.AG；OR=1.6；CI1.08-2.36；P=0.017)与卵巢癌的危险性增加显著相关。然而，未观察到rs237028基因多态与总生存期之间的显著关联。结论。本研究提示TAB2基因rs237028多态性与EOC易感性有关，TAB2基因可能参与了EOC的发生。
Background. Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-beta- (TGF-beta-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammatory and estrogen, may be implicated in EOC. The present study is aimed at exploring the association between the TAB2 gene polymorphisms and EOC. Methods. Three single nucleotide polymorphisms (SNPs) (rs237028, rs521845, and rs652921) of TAB2 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 221 patients and 252 healthy controls. Associations between SNPs and clinical characteristics were performed either with the chi(2) test or with Fisher's exact test. The Kaplan-Meier method and Cox proportional hazard models were used to detect associations between genotypes and overall survival. Results. The rs237028 polymorphism was significantly associated with an increased risk of EOC with an allelic genetic model (A vs. G; OR = 1.45; 95%CI = 1.07-1.96; P = 0.016), dominant genetic model (AA vs. AG-GG; OR = 1.66; CI 1.14-2.41; P = 0.008), and overdominant genetic model (AA-GG vs. AG; OR = 1.60; CI 1.08-2.36; P = 0.017). However, no significant association was observed between rs237028 polymorphism and overall survival. Conclusions. Our study indicated that the rs237028 polymorphism in the TAB2 gene was associated with EOC susceptibility and the TAB2 gene might contribute to the initiation of EOC.