Effect of a ginger extract on pregnancy-induced nausea: A randomised controlled trial
Effect of a ginger extract on pregnancy-induced nausea: A randomised controlled trial
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DOI：
10.1046/j.0004-8666.2003.00039.x
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发表时间：
2003-04-01
影响因子：
1.7
通讯作者：
Eden, JA
中科院分区：
文献类型：
--
作者：
Willetts, KE;Ekangaki, A;Eden, JA
目的：探讨生姜提取物EVEXT35对晨吐症状的影响。设计：双盲随机安慰剂对照试验。单位：城市三级教学医院，1999年3月- 1999年11月。参与者：参与者包括120名怀孕不到20周的妇女，她们每天都有孕吐，至少持续了一周，并且通过饮食改变没有缓解症状。干预：随机分配125毫克生姜提取物（EVEXT35；相当于1.5克干姜）或安慰剂，每天4次，持续4天。主要观察指标：恶心、呕吐和干呕（以罗兹恶心、呕吐和干呕指数衡量）。结果：治疗第一天后，生姜提取物组的恶心体验评分明显低于安慰剂组，并且这种差异在每个治疗日都存在。干呕也被姜提取物减少，虽然程度较轻。对呕吐无明显影响。与1999-2000年在皇家妇女医院出生的普通婴儿相比，对这些婴儿进行的妊娠随访显示，这些婴儿的出生体重、胎龄、阿普加评分和先天性异常频率范围正常。结论：生姜可以被认为是一种有效的治疗孕妇孕吐的选择。
Objective: To investigate the effect of a ginger extract (EVEXT35) on the symptoms of morning sickness.Design: Double-blind randomised placebo-controlled trial.Setting: A tertiary metropolitan teaching hospital, March 1999-November 1999.Participants: The participants included 120 women less than 20 weeks pregnant, who had experienced morning sickness daily for at least a week and had had no relief of symptoms through dietary changes.Intervention: Random allocation of 125 mg ginger extract (EVEXT35; equivalent to 1.5 g of dried ginger) or placebo given four times per day for 4 days.Main outcome measures: Nausea, vomiting and retching as measured by the Rhodes Index of Nausea, Vomiting and Retching.Results: The nausea experience score was significantly less for the ginger extract group relative to the placebo group after the first day of treatment and this difference was present for each treatment day. Retching was also reduced by the ginger extract although to a lesser extent. No significant effect was observed on vomiting. Follow-up of the pregnancies revealed normal ranges of birthweight, gestational age, Apgar scores and frequencies of congenital abnormalities when the study group infants were compared to the general population of infants born at the Royal Hospital for Women for the year 1999-2000.Conclusion: Ginger can be considered as a useful treatment option for women suffering from morning sickness.