VASCULAR ENDOTHELIUM RESPONDS TO FLUID SHEAR-STRESS GRADIENTS
VASCULAR ENDOTHELIUM RESPONDS TO FLUID SHEAR-STRESS GRADIENTS
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DOI：
10.1161/01.atv.12.11.1254
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发表时间：
1992-11-01
期刊：
影响因子：
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通讯作者：
DEWEY, CF
中科院分区：
文献类型：
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作者：
DEPAOLA, N;GIMBRONE, MA;DEWEY, CF
血管内皮对流体剪切应力的反应的体外研究通常在时间平均剪切应力均匀的条件下进行。相比之下，在体外实验报告在这里重新创建的表面流体剪切应力在体内动脉分支附近发现的大梯度，具体地说，我们已经产生了一个扰动流区域，包括流动分离和再附着。在再附着区附近，剪应力较小，但梯度较大。细胞迁移离开该区域，主要是在下游方向。与受到均匀剪切的细胞相比，那些保留下来的细胞以更高的速率分裂。我们推测，大的剪切应力梯度可以诱导形态和功能的变化，在内皮细胞的干扰流在体内的区域，从而可能有助于动脉粥样硬化病变的形成。
In vitro investigations of the responses of vascular endothelium to fluid shear stress have typically been conducted under conditions where the time-mean shear stress is uniform. In contrast, the in vitro experiments reported here have re-created the large gradients in surface fluid shear stress found near arterial branches in vivo; specifically, we have produced a disturbed-flow region that includes both flow separation and reattachment. Near reattachment regions, shear stress is small but its gradient is large. Cells migrate away from this region, predominantly in the downstream direction. Those that remain divide at a rate that is high compared with that of cells subjected to uniform shear. We speculate that large shear stress gradients can induce morphological and functional changes in the endothelium in regions of disturbed flow in vivo and thus may contribute to the formation of atherosclerotic lesions.