Distribution of five antigens in hepatocellular carcinoma.
Distribution of five antigens in hepatocellular carcinoma.
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五种抗原在肝细胞癌中的分布。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
H. Popper
中科院分区：
文献类型：
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作者：
S. Thung;M. Gerber;E. Sarno;H. Popper
肝细胞癌（HCC）患者的血清中可以检测到多种抗原。使用福尔马林固定的石蜡包埋组织，通过过氧化物酶-抗过氧化物酶技术检查了 37 个 HCC 中五种抗原的发生率和分布以及它们在给定肿瘤中彼此的关系。 α1-抗胰蛋白酶在 HCC 中频繁表达（73% 的病例），而甲胎蛋白和癌胚抗原则不太常见。在 HBsAg 阳性患者的 9 名 HCC 患者中有 7 名的肿瘤细胞中观察到 HBsAg，但未观察到 HBcAg。在 20 例 HCC（54%）中，检测到两种或多种抗原，最常见的是 α1-抗胰蛋白酶和甲胎蛋白。在同一组织切片中同时定位两种抗原的双重染色表明，尽管有些细胞同时展示两种抗原，但不同的肿瘤细胞中通常存在不同的抗原。这些发现表明，肝细胞癌细胞在功能上是异质的，即使它们在组织学上表现为单形性。
A variety of antigens may be detected in the serum of patients with hepatocellular carcinoma (HCC). The incidence and distribution of five antigens in 37 HCC and their relation to each other in a given tumor was examined by the peroxidase-antiperoxidase technique using formalin-fixed paraffin-embedded tissues. alpha 1-Antitrypsin was frequently expressed in HCC (73 per cent of cases), whereas alpha-fetoprotein and carcinoembryonic antigen were less common. HBsAg, but not HBcAg, was observed in tumor cells in seven of nine HCC from HBsAg-positive patients. In 20 HCC (54 per cent), two or more antigens, most frequently alpha 1-antitrypsin and alpha-fetoprotein, were detected. Double staining for simultaneous localization of two antigens in the same tissue section revealed that different antigens were usually present in different tumor cells, although some cells displayed two antigens simultaneously. These findings suggest that hepatocellular carcinoma cells are functionally heterogeneous, even if they appear histologically monomorphic.