Exploring the role of SlrR and SlrA in the SinR epigenetic switch.
Exploring the role of SlrR and SlrA in the SinR epigenetic switch.
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DOI：
10.4161/cib.25658
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发表时间：
2013-11-01
影响因子：
--
通讯作者：
Lewis RJ
中科院分区：
文献类型：
--
作者：
Newman JA;Lewis RJ
细菌生物膜正在成为一个重要的社会问题：生物膜形成牙菌斑，涂层船舶造成生物污垢，并坚持医疗器械和植入物。了解这些表面结合的社区是如何形成的是至关重要的发展适当的战略，他们的传播。在使芽孢杆菌和相关物种形成生物膜的开关的核心是一种称为SinR的转录调节因子及其多种拮抗剂。在本附录中，我们讨论了另一种模型来解释其中一种拮抗剂是如何通过控制蛋白水解来调节的。
Bacterial biofilms are becoming a significant societal problem: biofilms form dental plaque, coat ships causing biofouling, and cling onto medical instruments and implants. Understanding how these surface-bound communities are formed is crucial for the development of suitable strategies for their dispersal. At the heart of a switch that commits Bacilli and related species to form biofilms is a transcriptional regulator called SinR and its multiple antagonists. In this addendum, we discuss an alternative model to account for how one of the antagonists is regulated by controlled proteolysis.