Biogenesis of Nuclear Bodies
Biogenesis of Nuclear Bodies
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DOI：
10.1101/cshperspect.a000711
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发表时间：
2010-12-01
影响因子：
7.2
通讯作者：
Misteli, Tom
中科院分区：
文献类型：
--
作者：
Dundr, Miroslav;Misteli, Tom
细胞核在细胞器中是独特的，因为它包含无数离散的亚细胞器。这些核体在形态上和分子上是不同的实体，它们主持特定的核过程。虽然个体核体之间的生物发生模式似乎差异很大，但几个共同的设计原则正在出现，特别是核体从头形成的能力，RNA作为结构元件的作用和自组织作为形成模式。核体的受控生物发生对于细胞周期期间核结构的忠实维持是必不可少的，并且是细胞对细胞内和细胞外事件的反应的重要部分。
The nucleus is unique amongst cellular organelles in that it contains a myriad of discrete suborganelles. These nuclear bodies are morphologically and molecularly distinct entities, and they host specific nuclear processes. Although the mode of biogenesis appears to differ widely between individual nuclear bodies, several common design principles are emerging, particularly, the ability of nuclear bodies to form de novo, a role of RNA as a structural element and self-organization as a mode of formation. The controlled biogenesis of nuclear bodies is essential for faithful maintenance of nuclear architecture during the cell cycle and is an important part of cellular responses to intra-and extracellular events.