Simvastatin ameliorates glomerulosclerosis in Adriamycin-induced-nephropathy rats.
Simvastatin ameliorates glomerulosclerosis in Adriamycin-induced-nephropathy rats.
复制标题
辛伐他汀改善阿霉素肾病大鼠的肾小球硬化
DOI：
10.1007/s00467-008-0933-8
复制
发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Zhang W;Li Q;Wang L;Yang X
本研究旨在探讨3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶竞争性抑制剂辛伐他汀对阿霉素（ADR）肾病炎症和肾小球硬化的影响。雄性SD大鼠随机分为对照组、ADR肾病组和辛伐他汀治疗组。ADR肾病模型采用单尾静脉注射ADR（6.5mg/kg）建立。通过检测炎症介质白细胞介素-1 β（IL-1 β）、转化生长因子-β 1（TGF-β 1）和转录因子核因子κ B（NF-κ B）的表达来研究辛伐他汀的抗炎作用。此外，还比较了两组间的肾功能、血脂水平和组织病理学。注射ADR后12周，辛伐他汀可显著降低IL-1 β、TGF-β 1的表达和NF-κ B的活化，并伴有肾小球硬化和肾功能的显著减轻，这些变化发生在血脂不降低的情况下。这些结果表明，在肾脏区域的过度炎症可能有助于发展肾小球硬化的ADR诱导的肾病大鼠，和辛伐他汀治疗防止肾小球硬化的降脂作用无关。辛伐他汀的有益作用可能是通过减少NF-κ B活化、IL-1 β和TGF-β表达而发挥抗炎作用。
The aim of this study was to investigate the effects of simvastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, on inflammation and glomerulosclerosis in Adriamycin (ADR)-induced nephropathy. Male Sprague-Dawley rats were randomly divided into control, ADR nephrosis, and simvastatin-treated ADR nephrosis groups. ADR nephropathy was induced by a single-tail intravenous injection of ADR (6.5 mg/kg). Anti-inflammatory effects of simvastatin were studied by evaluating the expression of the inflammatory mediators interleukin-1 beta (IL-1β), transforming growth factor-β1 (TGF-β1), and transcription factor nuclear factor kappa B (NF-κB). In addition, renal function, serum lipid levels, and histopathology were compared between groups. Simvastatin significantly decreases IL-1β and TGF-β1 expression and NF-κB activation, accompanied by significant attenuation of glomerulosclerosis and renal function at 12 weeks after ADR injection, and these changes occurred in the absence of lowering of serum lipids. These results suggest that overexpression of inflammation in the renal region may contribute to development of glomerulosclerosis in ADR-induced-nephropathy rats, and simvastatin treatment prevented glomerulosclerosis independent of the lipid-lowering effects. The beneficial effect of simvastatin might be mediated by the effect of anti-inflammatory action through a reduction of NF-κB activation, and IL-1β and TGF-β expression.
登录
查看更多内容
影响因子：
4.2
作者：
Navarro, Juan F.;Milena, Francisco J.;Garcia, Javier
通讯作者：
Garcia, Javier
影响因子：
13.6
作者：
Bussolati, B;Deregibus, MC;Camussi, G
通讯作者：
Camussi, G
影响因子：
19.6
作者：
KARKAR, AM;TAM, FWK;REES, AJ
通讯作者：
REES, AJ
DOI：
10.1097/01.asn.0000115704.86897.f4
发表时间：
2004-04-01
影响因子：
13.6
作者：
Timoshanko, JR;Kitching, AR;Tipping, PG
通讯作者：
Tipping, PG
DOI：
10.1152/ajpheart.2000.279.6.h2786
发表时间：
2000-12-01
影响因子：
4.8
作者：
Ye, SH;Mozayeni, P;Campese, VM
通讯作者：
Campese, VM