Microbial cancer therapeutics: A promising approach
Microbial cancer therapeutics: A promising approach
复制标题
微生物癌症疗法：一种有前途的方法
DOI：
10.1016/j.semcancer.2021.05.003
复制
发表时间：
2022-10-19
影响因子：
14.5
通讯作者：
Gupta，Vijai Kumar
中科院分区：
文献类型：
--
作者：
Diwan，Deepti;Cheng，Lei;Gupta，Vijai Kumar
传统癌症治疗的成功受到抗生素耐药性相关可怕副作用以及抗肿瘤药物缺乏选择性和特异性的阻碍。因此，选择性靶向癌细胞而不影响健康细胞或组织的抗癌治疗剂的概念演变引发了对微生物衍生的生物活性分子的新一波科学兴趣。这些战略解决方案可能为克服传统疗法的缺点铺平道路，并提高选择性治愈多种癌症的潜力和希望。本综述旨在全面总结微生物来源的生物活性分子的抗癌特性和潜在机制，并讨论当前的挑战和组合策略的有效治疗应用，以实现最小的全身副作用。
The success of conventional cancer therapeutics is hindered by associated dreadful side-effects of antibiotic resistance and the dearth of antitumor drugs' selectivity and specificity. Hence, the conceptual evolution of anti-cancerous therapeutic agents that selectively target cancer cells without impacting the healthy cells or tissues, has led to a new wave of scientific interest in microbial-derived bioactive molecules. Such strategic solutions may pave the way to surmount the shortcomings of conventional therapies and raise the potential and hope for the cure of wide range of cancer in a selective manner. This review aims to provide a comprehensive summary of anti-carcinogenic properties and underlying mechanisms of bioactive molecules of microbial origin, and discuss the current challenges and effective therapeutic application of combinatorial strategies to attain minimal systemic side-effects.