Multidrug resistance in Yersinia pestis mediated by a transferable plasmid
Multidrug resistance in Yersinia pestis mediated by a transferable plasmid
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DOI：
10.1056/nejm199709043371004
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发表时间：
1997-09-04
影响因子：
158.5
通讯作者：
Courvalin, P
中科院分区：
文献类型：
--
作者：
Galimand, M;Guiyoule, A;Courvalin, P
鼠疫耶尔森氏菌是鼠疫的病原体，鼠疫是一种人畜共患疾病，通过跳蚤叮咬传播给人类，典型特征是出现淋巴结肿大（即腹股沟淋巴结炎）。人与人之间的传播可以通过跳蚤叮咬（黑死病）或呼吸道飞沫进行，从而引起称为肺鼠疫的压倒性感染。上一次鼠疫大流行于 1894 年在香港开始，随后蔓延到世界各地，形成了许多地方性疫源地。抗生素和公共卫生措施的实施显着降低了与该疾病相关的发病率和死亡率，但并未使其根除。事实上，瘟疫。 。 。
Yersinia pestisis the causative agent of plague, a zoonotic disease transmitted to humans through flea bites and typically characterized by the appearance of a tender and swollen lymph node, the bubo. Human-to-human transmission can occur, through either the bite of fleas (bubonic plague) or respiratory droplets, causing an overwhelming infection called pneumonic plague.The last plague pandemic began in Hong Kong in 1894 and spread throughout the world, establishing many endemic foci. Antibiotics and enforcement of public health measures significantly decreased the morbidity and mortality associated with the disease but did not allow its eradication. In fact, plague . . .