Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine
Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine
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DOI：
10.1002/adfm.201605271
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发表时间：
2017-04-18
影响因子：
19
通讯作者：
De, Sayan
中科院分区：
文献类型：
--
作者：
Tricoli, Antonio;Nasiri, Noushin;De, Sayan
上个世纪前所未有的医学成就极大地提高了我们的生活质量。如今，许多医疗保健方法的高成本对其长期财务可持续性和向全球范围的转化构成了挑战。可穿戴电子设备、微型传感器技术和大数据分析的融合为提高医疗质量提供了新的机会，同时通过早期检测和预防致命和慢性疾病来降低成本。在这里，一些令人兴奋的成就，新兴技术，以及非侵入性个性化和预防性医疗设备的发展面临的挑战进行了讨论。审查了可穿戴生物相容性材料上的无导线和无功率超薄传感器的工程，这些材料可以放置在皮肤，瞳孔和牙齿上，重点关注常见的解决方案和当前的限制。介绍了复杂传感纳米材料的集成和开发，并展示了检测人体汗液和呼吸等复杂混合物中超低浓度生物标志物的示例性实施方案。本文最后总结了微型化医学传感器技术的研究成果和面临的挑战，旨在为未来的研究提供方向。
The unprecedented medical achievements of the last century have dramatically improved our quality of life. Today, the high cost of many healthcare approaches challenges their long-term financial sustainability and translation to a global scale. The convergence of wearable electronics, miniaturized sensor technologies, and big data analysis provides novel opportunities to improve the quality of healthcare while decreasing costs by the very early stage detection and prevention of fatal and chronic diseases. Here, some exciting achievements, emerging technologies, and standing challenges for the development of non-invasive personalized and preventive medicine devices are discussed. The engineering of wire-and power-less ultra-thin sensors on wearable biocompatible materials that can be placed on the skin, pupil, and teeth is reviewed, focusing on common solutions and current limitations. The integration and development of sophisticated sensing nano-materials are presented with respect to their performance, showing exemplary implementations for the detection of ultra-low concentrations of biomarkers in complex mixtures such as the human sweat and breath. This review is concluded by summarizing achievements and standing challenges with the aim to provide directions for future research in miniaturized medical sensor technologies.