Development of dry powder inhalers.
Development of dry powder inhalers.
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DOI：
10.2174/187221107779814159
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Misra, Ambikanandan
中科院分区：
文献类型：
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作者：
Chougule, Mahavir B;Padhi, Bijay K;Misra, Ambikanandan
干粉吸入器的开发涉及粉末再结晶、配方、分散、输送和治疗剂在气道不同区域的沉积，以预防/治疗/诊断肺部和全身疾病。传统的结晶和磨粉生产存在许多局限性，因此需要开发替代技术来克服这些问题。在过去的十年中，许多专利已经提交，声称通过使用(i)结合细粒载体颗粒占据表面活性位点，并使用疏水载体通过减少表面能和颗粒相互作用来促进解聚（ii）通过颗粒工程和将药物纳入多孔或低颗粒密度来减少空气动力学直径，从而改善干粉吸入器的气溶胶性能。和/或（iii）通过波纹表面，低堆积密度，降低表面能和颗粒相互作用以及疏水添加剂制备凝聚力和粘附性较低的颗粒。干粉吸入器（DPI）产品中的水分也被证明通过毛细管力和静电相互作用影响气溶胶性能。通过使用复杂的分析技术，对粒子力和表面能有了更好的理解。了解影响特定肺沉积的颗粒形状和表面性质的复杂性已经进一步促进了更新和先进软件的可用性。对最近声称采用不同方法改善干粉吸入器肺沉积的专利进行批判性审查，将有助于确定技术差距领域的研究重点。
Development of dry powder inhalers involves powder recrystallization, formulation, dispersion, delivery, and deposition of the therapeutic agent in different regions of the airways in prophylaxis/ treatment/ diagnosis of pulmonary and systemic disorders. Conventional powder production by crystallization and milling has many limitations resulting into development of alternative techniques to overcome the problems. In the last decade many patents have been filed claiming improvement in aerosol performance of dry powder inhalers through the use of (i) incorporation of fines of carrier particles to occupy active sites on the surface and use of hydrophobic carriers to facilitate deaggregation through reduced surface energy and particle interaction (ii) reducing aerodynamic diameters through particle engineering and incorporating drug into porous or low particle density, and/or (iii) preparing less cohesive and adhesive particles through corrugated surfaces, low bulk density, reduced surface energy and particle interaction and hydrophobic additives. Moisture within dry powder inhaler (DPI) products has also been shown to influence aerosol performance via capillary force and electrostatic interaction. Better understanding of particle forces and surface energy has been achieved by the use of sophisticated analytical techniques. Understanding the intricacies of particle shape and surface properties influencing specific lung deposition has been further facilitated by the availability of newer and advanced softwares. A critical review of recent patents claiming different approaches to improve lung deposition of dry powder inhalers will help in deciding the focus of the research in the area of technological gaps.