Age, sex, and the familial risk of rheumatoid arthritis.
Age, sex, and the familial risk of rheumatoid arthritis.
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年龄、性别和类风湿性关节炎的家族风险。
DOI：
10.1093/oxfordjournals.aje.a008850
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发表时间：
1996
影响因子：
5
通讯作者：
Chakravarti,A
中科院分区：
文献类型：
--
作者：
Kwoh,CK;Venglish,C;Lynn,AH;Whitley,DM;Young,E;Chakravarti,A
对1987年1月1日至1987年3月31日期间确诊的165例风湿性关节炎患者的一级亲属进行了类风湿性关节炎家族聚集性研究，以确定影响其风险的因素。而不考虑关于其家庭成员中发生类风湿性关节炎的先前信息。通过结构化临床评估验证的一级亲属的情感状态报告显示，家庭成员的假阳性报告率为61%。相比之下，没有发现假阴性病例。135个单纯型和30个多重型家庭的平均家庭规模或患病总年数没有差异;然而，聚集分析显示，30个确认的多重型家庭中只有18个具有显著的类风湿关节炎超额风险。显着差异时，发现先证者从多重家庭的女性与男性的比例为先证者（1：1的多重家庭与3：1的单纯家庭）和平均发病年龄为先证者（41岁的多重家庭与48岁的单纯家庭）进行了比较，从单纯家庭。类风湿性关节炎的家族风险在父母（4.2%）和兄弟姐妹（4.6%）中相似，先证者的子女（0.7%）最低。作者断言，类风湿性关节炎患者的一级亲属的情感状态经常被错误地报告为阳性。类风湿性关节炎的家族性可能与受影响家族成员发病时的性别和年龄有更准确的关系。美国流行病学杂志1996; 144：15-24。
The familial aggregation of rheumatoid arthritis was examined to determine factors modifying the risk of rheumatoid arthritis in first degree relatives of 165 cases ascertained from January 1, 1987, through March 31, 1987, using the Saint Margaret Memorial Hospital Rheumatoid Arthritis Registry, Pittsburgh, Pennsylvania, without regard to previous information conceming the occurrence of rheumatoid arthritis among their family members. The reported affection status of first degree relatives, verified through a structured clinical evaluation, revealed a false-positive reporting rate for family members of 61%. In contrast, there were no false-negative cases detected. There were no differences in average family size or total number of years at risk between 135 simplex and 30 multiplex families; however, aggregation analysis revealed that only 18 of 30 confirmed multiplex families had significant excess risk of rheumatoid arthritis. Significant differences were found when probands from multiplex families were compared with those from simplex families with regard to female to male ratio for probands (1: 1 in multiplex families vs. 3: 1 in simplex families) and average age of onset for probands (41 years in multiplex families vs. 48 years in simplex families). The familial risk for rheumatoid arthritis was similar in parents (4.2%) and siblings (4.6%) and lowest for children (0.7%) of probands. The authors assert that the affection status of first degree relatives of patients with rheumatoid arthritis is often falsely reported as positive. The familialrty of rheumatoid arthritis may be more accurately related to the sex and age at onset of the affected family member.Am J Epidemiol1996; 144: 15–24.