Relationship between type IV collagen degradation, metalloproteinase activity and smooth muscle cell migration and proliferation in cultured human saphenous vein
Relationship between type IV collagen degradation, metalloproteinase activity and smooth muscle cell migration and proliferation in cultured human saphenous vein
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DOI：
10.1016/s0008-6363(03)00256-6
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发表时间：
2003-06-01
影响因子：
10.8
通讯作者：
Newby, AC
中科院分区：
文献类型：
--
作者：
Aguilera, CM;George, SJ;Newby, AC
基底膜降解、金属蛋白酶（MMP）活性和平滑肌细胞（SMC）迁移和增殖之间的关系尚未在任何干预研究中进行过研究。我们在培养的人隐静脉中使用了金属蛋白酶组织抑制剂（TIMPs）的腺病毒过表达。通过免疫细胞化学，基底膜IV型胶原（Coll-IV）包围的中膜SMC百分比从93+/-1降至77+/-4%和82+/-1%（n=18，均P
The relationship between degradation of basement membranes, metalloproteinase (MMP) activity and smooth muscle cell (SMC) migration and proliferation has not been previously investigated in any intervention study. We used adenoviral overexpression of tissue inhibitors of metalloproteinases (TIMPs) in cultured human saphenous veins. By immunocytochemistry, the percentage of medial SMC surrounded by basement membrane type IV collagen (Coll-IV) decreased from 93+/-1 to 77+/-4% and 82+/-1% (n=18, both P