Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.
Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.
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DOI：
10.1111/obr.12524
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Chambers TJG
中科院分区：
文献类型：
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作者：
Ribaroff GA;Wastnedge E;Drake AJ;Sharpe RM;Chambers TJG
母体高脂饮食（HFD）的动物模型表现出后代代谢紊乱，尽管模型之间的影响显着不同。我们评估了研究HFD喂养母亲后代代谢参数的研究，以确定解释这些研究间差异的因素。共识别出171篇论文，提供了6047名后代的数据。提取关于体重、肥胖、葡萄糖稳态和脂血症的数据。收集有关饮食中常量营养素含量、物种、暴露时间点和妊娠期体重增加的信息，并用于Meta回归模型，以探索预测因素。使用Egger回归检验评估发表偏倚。母体HFD暴露不影响后代的出生体重，但增加断奶体重，最终体重，肥胖，血脂，胆固醇血症和胰岛素血症的女性和男性后代。仅在雌性后代中发现高脂血症。Meta-回归分析确定哺乳期HFD暴露为关键调节因素。饮食中的脂肪含量与任何结果无关。有证据表明，除出生体重外，所有结局均存在显著的出版偏倚。母体HFD暴露与后代代谢紊乱有关，但研究之间不考虑饮食成分、物种、品系或母体妊娠期体重增加。实验设计中的具体弱点使许多结果容易产生偏差。
Animal models of maternal high fat diet (HFD) demonstrate perturbed offspring metabolism although the effects differ markedly between models. We assessed studies investigating metabolic parameters in the offspring of HFD fed mothers to identify factors explaining these inter‐study differences. A total of 171 papers were identified, which provided data from 6047 offspring. Data were extracted regarding body weight, adiposity, glucose homeostasis and lipidaemia. Information regarding the macronutrient content of diet, species, time point of exposure and gestational weight gain were collected and utilized in meta‐regression models to explore predictive factors. Publication bias was assessed using Egger's regression test. Maternal HFD exposure did not affect offspring birthweight but increased weaning weight, final bodyweight, adiposity, triglyceridaemia, cholesterolaemia and insulinaemia in both female and male offspring. Hyperglycaemia was found in female offspring only. Meta‐regression analysis identified lactational HFD exposure as a key moderator. The fat content of the diet did not correlate with any outcomes. There was evidence of significant publication bias for all outcomes except birthweight. Maternal HFD exposure was associated with perturbed metabolism in offspring but between studies was not accounted for by dietary constituents, species, strain or maternal gestational weight gain. Specific weaknesses in experimental design predispose many of the results to bias.