Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease.
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease.
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DOI：
10.1016/s1473-3099(05)01308-3
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发表时间：
2005-03
期刊：
影响因子：
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通讯作者：
N. W. Schröder;R. Schumann
中科院分区：
文献类型：
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作者：
N. W. Schröder;R. Schumann
toll样受体（TLRs）在入侵微生物的先天免疫识别中发挥重要作用，启动足够的免疫反应。越来越多的数据表明，某些个体对TLR配体作出适当反应的能力可能会受到TLR基因内单核苷酸多态性（snp）的损害，从而导致对感染性或炎症性疾病的易感性或病程发生改变。大多数研究集中在编码细菌脂多糖受体TLR4基因中的两个共聚snp - asp299gly和thr399ile。这些snp存在于大约10%的白人个体中，并且被发现与几种传染病呈正相关。然而，这些snp似乎可以预防动脉粥样硬化和相关疾病，本文也对此进行了综述。与此同时，编码其他tlrs的基因的snp（如识别多种微生物配体的TLR2）已被报道，初步研究表明其也对感染性和炎症性疾病的易感性有影响。这篇综述总结和讨论了所获得的结果，并从这些数据中得出结论。
Toll-like receptors (TLRs) play an important part in the innate immune recognition of invading microorganisms, initiating sufficient immune responses. Growing amounts of data suggest that the ability of certain individuals to respond properly to TLR ligands may be impaired by single nucleotide polymorphisms (SNPs) within TLR genes, resulting in an altered susceptibility to, or course of, infectious or inflammatory disease. Most studies have focused on two cosegregating SNPs—Asp299Gly and Thr399Ile—within the gene encoding TLR4, the receptor for bacterial lipopolysaccharide. These SNPs are present in approximately 10% of white individuals, and have been found to be positively correlated with several infectious diseases. However, these SNPs seem to protect from atherosclerosis and related diseases, which is reviewed in this article also. Meanwhile, SNPs of genes encoding other TLRs—eg, TLR2, which recognises a wide variety of microbial ligands—have been reported, and preliminary studies indicate an impact on susceptibility to infectious and inflammatory diseases as well. This review summarises and discusses the results obtained, and draws conclusions from these data.