DNA damage, p53, apoptosis and vascular disease
DNA damage, p53, apoptosis and vascular disease
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DOI：
10.1016/j.mrfmmm.2007.02.011
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发表时间：
2007-08-01
影响因子：
2.3
通讯作者：
Bennett, Martin
中科院分区：
文献类型：
--
作者：
Mercer, John;Mahmoudi, Melli;Bennett, Martin
动脉粥样硬化是西方世界最常见的死亡原因。动脉粥样硬化斑块显示DNA损伤、损伤修复途径激活、p53表达和凋亡的证据，涉及多种不同的细胞类型。本文综述了动脉粥样硬化中DNA损伤的证据，可能的刺激诱导损伤，以及p53在动脉粥样硬化中介导细胞凋亡及其后果中的作用。(C) 2007 Elsevier B.V.版权所有
Atherosclerosis is the commonest cause of death in the Western world. The atherosclerotic plaque shows evidence of DNA damage, activation of damage repair pathways, p53 expression and apoptosis, involving a variety of different cell types. This review summarises the evidence for DNA damage in atherosclerosis, the likely stimuli inducing damage, and the increasing role of p53 in mediating apoptosis and its consequences in atherosclerosis. (C) 2007 Elsevier B.V. All rights reserved.