Effect of dexamethasone on plasma prolactin and cortisol levels in psychiatric patients.
Effect of dexamethasone on plasma prolactin and cortisol levels in psychiatric patients.
复制标题
地塞米松对精神病患者血浆催乳素和皮质醇水平的影响。
DOI：
10.1176/ajp.139.6.763
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Piyaka,SK
中科院分区：
文献类型：
--
作者：
Meltzer,HY;Fang,VS;Tricou,BJ;Robertson,A;Piyaka,SK
除了能够降低血浆皮质醇水平外，地塞米松还可显著降低血浆催乳素水平。在52例精神病患者中，包括26例原发性重性抑郁症或情感性抑郁症，主要是情感型，有一个显着的关联，血浆皮质醇和催乳素的非抑制后，地塞米松。这些结果表明，在某些精神病患者中，皮质醇对地塞米松的异常反应可能是由于脑垂体异常，而不是边缘系统异常。地塞米松抑制试验对内源性抑郁症的敏感性和特异性均低于以前的报道。
In addition to its ability to decrease plasma cortisol levels, dexamethasone can also significantly decrease plasma prolactin levels. In 52 psychiatric patients, including 26 patients with primary major depression or schizoaffective depression, primarily affective type, there was a significant association between nonsuppression of plasma cortisol and prolactin after administration of dexamethasone. These results suggest that the abnormal cortisol response to dexamethasone in some psychiatric patients may be due to a pituitary gland abnormality rather than to a limbic system abnormality. The sensitivity and specificity of the dexamethasone suppression test for endogenous depression were less than previously reported.