Wall shear stress and early atherosclerotic lesions in the abdominal aorta in young adults
Wall shear stress and early atherosclerotic lesions in the abdominal aorta in young adults
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DOI：
10.1016/s1078-5884(97)80171-2
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发表时间：
1997-05-01
影响因子：
5.7
通讯作者：
Yoganathan, AP
中科院分区：
文献类型：
--
作者：
Pedersen, EM;Agerbaek, M;Yoganathan, AP
目的：研究腹主动脉壁切应力与早期动脉粥样硬化病变的相关性。材料：腹主动脉血流动力学模拟在一个现实的脉动爪模型。从10个年轻的成年人没有动脉粥样硬化diseases.Methods的迹象，获得腹部aerodynamics：定量壁剪切应力测量背心和运动在一个肾上腺和两个肾下的位置，使用激光多普勒风速仪。采用组织形态学方法在相应位置盲测内膜增厚指数，并采用线性回归分析与壁切应力变量进行比较。结果：内膜厚度指数随年龄增长而显着增加。肾上主动脉内膜厚度指数显著低于肾下主动脉，血管远端后壁内膜厚度指数显著高于前壁。内膜厚度指数与静息时测量的平均、最小和振荡壁剪应力显着相关。结论：未患病腹主动脉的内膜厚度与脉动流模型中测量的静息时平均、最小和振荡壁剪应力显着相关。最大剪应力参数之间无相关性。运动改变了局部壁面剪应力远离与内膜厚度指数相关的特征。
Objectives: To study the correlation between wall shear stress and early atherosclerotic lesions in the abdominal aorta.Design: Blinded histomorphometric studies. Comparison with in vitro data.Materials: Abdominal aortic haemodynamics were simulated in a realistic pulsatile paw model. Abdominal aortas from 10 young adults with no signs of atherosclerotic disease were obtained during autopsy.Methods: Quantitative wall shear stresses were measured at vest and exercise in one suprarenal and two infrarenal positions using laser Doppler anemometry. Intimal thickening indices were measured blindedly at the corresponding locations using histomorphometric methods, and compared to wall shear stress variables using linear regression analysis.Results: Intimal thickness index increased significantly with age. Intimal thickness index teas significantly lower in the suprarenal than the infrarenal aorta, and higher at the distal posterior vessel wall compared to the anterior wall. Intimal thickness index correlated significantly with mean, minimum and oscillating wall shear stresses measured at rest.Conclusion: Intimal thickness in the undiseased abdominal aorta correlated significantly with mean, minimum and oscillating wall shear stresses at rest measured in a pulsatile flow model. No correlations were found with maximum shear stress parameters. Exercise changed the local wall shear stresses away from the characteristics associated with intimal thickness index.