3D engineering for optic neuropathy treatment.
3D engineering for optic neuropathy treatment.
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DOI：
10.1016/j.drudis.2020.09.034
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发表时间：
2021-01
影响因子：
7.4
通讯作者：
Xu Q
中科院分区：
文献类型：
--
作者：
Xuan W;Moothedathu AA;Meng T;Gibson DC;Zheng J;Xu Q
眼部疾病，如年龄相关性黄斑变性（AMD）、糖尿病性视网膜病变（DR）、色素性视网膜炎（RP）和青光眼，可引起不可逆的视力丧失，并影响数百万患者的生活质量。然而，只有很少的3D系统可以模拟人类眼部病理生理学，特别是视网膜退行性疾病，其涉及视网膜神经节细胞（RGC）、光感受器或视网膜色素上皮细胞（RPE）的损失。本文就眼组织三维建模的研究进展进行综述，并根据相关疾病模型的分类，对上述技术在视神经病变治疗中的应用及其在药物筛选、机制研究、细胞和基因治疗中的应用进行综述。3D模型可以减少动物试验，评估靶向药物递送，加速药物开发过程;它们在细胞和基因治疗中也有很好的应用前景，特别是对于难以在体内模拟的视网膜退行性疾病和/或视神经病变。
Ocular disorders, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa (RP), and glaucoma, can cause irreversible visual loss, and affect the quality of life of millions of patients. However, only very few 3D systems can mimic human ocular pathophysiology, especially the retinal degenerative diseases, which involve the loss of retinal ganglion cells (RGCs), photoreceptors, or retinal pigment epithelial cells (RPEs). In this review, we discuss current progress in the 3D modeling of ocular tissues, and review the use of the aforementioned technologies for optic neuropathy treatment according to the categories of associated disease models and their applications in drug screening, mechanism studies, and cell and gene therapies. 3D models can reduce animal testing, evaluate targeted drug delivery, and accelerate drug development process; they also have promising applications in cell and gene therapies, especially for retinal degenerative diseases and/or optic neuropathies that are difficult to mimic in vivo.
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