Adverse Childhood Experiences and Lower Urinary Tract Symptoms and Impact Among Women.
Adverse Childhood Experiences and Lower Urinary Tract Symptoms and Impact Among Women.
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不良童年经历和下尿路症状及其对女性的影响。
DOI：
10.1097/ju.0000000000003387
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Markland,AlayneD
中科院分区：
文献类型：
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作者：
Brady,SonyaS;Arguedas,Andrés;Huling,JaredD;Shan,Liang;Lewis,CoraE;Fok,CynthiaS;VanDenEeden,StephenK;Markland,AlayneD
目的：本研究利用CARDIA（年轻人冠状动脉风险发展）队列研究数据，以检查（1）以家庭为基础的不良童年经历，回顾32至47岁的妇女，与下尿路症状及其影响，复合变量与4个级别（膀胱健康和轻度，中度，或重度下尿路症状/影响），和（2）广泛的妇女的社交网络在成年衰减不良童年经历和下尿路症状/impact.Materials和方法之间的关联：在2000-2001年，不良童年经历暴露的频率进行了回顾性评估。在2000-2001年、2005-2006年和2010-2011年，对社交网络的广泛性进行了评估;分数取平均值。2012-2013年，收集了下尿路症状/影响数据。Logistic回归分析检查是否不良的童年经历，广泛的社交网络，以及他们的相互作用与下尿路症状/影响，调整年龄，种族，教育，和parity（n= 1，302）。结果：回忆更频繁的家庭为基础的不良童年经历与更多的下尿路症状/影响的报告超过10年后（OR= 1.26，95%CI = 1.07，1.48）。成年期的社交网络似乎减弱了儿童期不良经历与下尿路症状/影响之间的关联（OR= 0.64，95%CI = 0.41，1.02）。在社交网络不太广泛的女性中，对于报告不良儿童经历频率超过“一点”与“很少或没有”的女性，经历中度或重度下尿路症状/影响与膀胱健康或轻度下尿路症状/影响的估计概率分别为0.29和0.21。在妇女更广泛的社交网络，估计概率分别为0.20和0.21，respectively.Conclusions：以家庭为基础的不良童年经历与下尿路症状/影响与膀胱健康在成年期。需要进一步的研究来证实社交网络的潜在衰减效应。
Purpose:This study utilizes CARDIA (Coronary Artery Risk Development in Young Adults) cohort study data to examine whether (1) family-based adverse childhood experiences, recalled by women aged 32 to 47, are associated with lower urinary tract symptoms and their impact, a composite variable with 4 levels (bladder health and mild, moderate, or severe lower urinary tract symptoms/impact), and (2) extensiveness of women’s social networks in adulthood attenuates an association between adverse childhood experiences and lower urinary tract symptoms/impact.Materials and Methods:In 2000-2001, frequency of adverse childhood experiences exposure was retrospectively assessed. In 2000-2001, 2005-2006, and 2010-2011, extensiveness of social networks was assessed; scores were averaged. In 2012-2013, lower urinary tract symptoms/impact data were collected. Logistic regression analyses examined whether adverse childhood experiences, extensiveness of social networks, and their interaction were associated with lower urinary tract symptoms/impact, adjusting for age, race, education, and parity (n= 1,302).Results:Recall of more frequent family-based adverse childhood experiences was associated with report of more lower urinary tract symptoms/impact over 10 years later (OR= 1.26, 95% CI= 1.07, 1.48). Social networks during adulthood appeared to attenuate the association between adverse childhood experiences and lower urinary tract symptoms/impact (OR= 0.64, 95% CI= 0.41, 1.02). Among women with less extensive social networks, estimated probability of experiencing moderate or severe lower urinary tract symptoms/impact vs bladder health or mild lower urinary tract symptoms/impact was 0.29 and 0.21 for those reporting an adverse childhood experiences frequency corresponding to more than “a little” vs “rarely or none of the time,” respectively. Among women with more extensive social networks, estimated probabilities were 0.20 and 0.21, respectively.Conclusions:Family-based adverse childhood experiences are related to lower urinary tract symptoms/impact vs bladder health in adulthood. Additional research is needed to corroborate the potentially attenuating effect of social networks.