Wnt signaling in liver cancer.
Wnt signaling in liver cancer.
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DOI：
10.2174/138945008786786127
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发表时间：
2008-11
影响因子：
3.2
通讯作者：
Brown AM
中科院分区：
文献类型：
--
作者：
Takigawa Y;Brown AM
肝细胞癌是世界范围内癌症死亡的主要原因。与许多其他类型的癌症一样，规范的Wnt/β-Catenin信号通路的异常激活是肿瘤发生的重要因素。在肝细胞癌中，这通常是通过β-连环蛋白N端区域的突变来发生的，该突变稳定了蛋白质，并允许β-连环蛋白/TcF复合体提高了结构性转录激活水平。本文综述了Wnt/β-catenin信号转导通路参与肝癌发生的大量证据。我们还讨论了Wnt信号在肝脏发育、再生和干细胞行为中的作用，以努力了解规范的Wnt途径激活促进该器官肿瘤形成的机制。Wnt/β-Catenin通路是开发新的合理肝癌治疗方法的一个有吸引力的靶点，目前对这种疾病几乎没有成功的治疗策略。
Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. As in many other types of cancer, aberrant activation of the canonical Wnt/β-catenin signaling pathway is an important contributor to tumorigenesis. In HCC this frequently occurs through mutations in the N-terminal region of β-catenin that stabilize the protein and permit an elevated level of constitutive transcriptional activation by β-catenin/TCF complexes. In this article we review the abundant evidence that Wnt/β-catenin signaling contributes to liver carcinogenesis. We also discuss what is known about the roles of Wnt signaling in liver development, regeneration, and stem cell behavior, in an effort to understand the mechanisms by which activation of the canonical Wnt pathway promotes tumor formation in this organ. The Wnt/β-catenin pathway presents itself as an attractive target for developing novel rational therapies for HCC, a disease for which few successful treatment strategies are currently available.