Natural killer cells in patients with severe chronic fatigue syndrome.
Natural killer cells in patients with severe chronic fatigue syndrome.
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DOI：
10.1007/s13317-013-0051-x
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发表时间：
2013-12
影响因子：
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通讯作者：
Marshall-Gradisnik, S M
中科院分区：
文献类型：
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作者：
Brenu, E W;Hardcastle, S L;Atkinson, G M;van Driel, M L;Kreijkamp-Kaspers, S;Ashton, K J;Staines, D R;Marshall-Gradisnik, S M
维持健康和生理稳态是一个协同的过程，涉及蛋白质，转录因子和其他分子过程的紧密调控。免疫系统由维持免疫所需的先天性和适应性免疫细胞组成。病原体和肿瘤细胞的存在激活先天免疫细胞，特别是自然杀伤（NK）细胞。NK受体的随机表达激活抑制性或激活性信号，并导致细胞因子产生和导致靶细胞凋亡的途径的激活。因此，NK细胞是免疫过程和其功能过程中的畸变的必要组分，包括NK细胞和细胞毒性活性的不确定水平预先阻止复发性病毒感染、自身免疫性疾病和改变的炎症反应。NK细胞与许多疾病有关，包括慢性疲劳综合征（CFS）。本综述的目的是突出报道CFS患者中NK细胞的不同特征，并根据症状的严重程度确定CFS患者亚型中NK免疫功能障碍的程度。本文的在线版本（doi：10.1007/s13317-013-0051-x）包含补充材料，可供授权用户使用。
Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms. The online version of this article (doi:10.1007/s13317-013-0051-x) contains supplementary material, which is available to authorized users.