Telomeres in disease.
Telomeres in disease.
复制标题
DOI：
10.3410/m4-8
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Young N
中科院分区：
文献类型：
--
作者：
Calado R;Young N
端粒和端粒修复是拥有线性DNA染色体的细胞的基本分子特征，端粒缺陷会导致各种疾病。这篇综述探讨了了解这些疾病（特别是在分子水平）以及将端粒功能障碍与临床疾病联系起来的最新进展。我们还讨论了端粒延长作为疾病治疗的潜在作用，以及更具争议性的预防/逆转衰老的潜在作用。
Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects in them result in various diseases. This review examines recent advances in understanding these diseases, particularly at a molecular level, and in relating telomere dysfunction to clinical diseases. We also discuss the potential role of telomere elongation as a therapy in diseases, and more controversially, the prevention/reversal of aging.