Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells
Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells
复制标题
C70-羧基富勒烯作为高效抗癌细胞敏化剂的结构效应和机制
DOI：
10.1002/smll.201200158
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发表时间：
2012-07-09
期刊：
影响因子：
13.3
通讯作者：
Wang, Chunru
中科院分区：
文献类型：
--
作者：
Liu, Qiaoling;Guan, Mirong;Wang, Chunru
测试了具有不同加合数和笼尺寸的羧基富勒烯作为光动力疗法（PDT）的光敏剂。这些羧基富勒烯的光动力学效率主要取决于笼的大小，C60与C70，并在较小程度上的加合物数。特别地，丙二酸修饰的C70富勒烯比它们的C60对应物作为光敏剂更有效，并且详细研究了C70-羧基富勒烯在光照射下诱导细胞死亡的机制。结果表明，细胞死亡通过坏死伴随膜起泡发生，这是光敏剂诱导的细胞死亡的独特现象。由于C70-羧基富勒烯显示出有效的PDT性质和可忽略的暗细胞毒性，因此它有希望用于PDT应用，特别是通常发生在表面下的血管毛细血管疾病。
Carboxyfullerenes with different adduct numbers and cage sizes are tested as photosensitizers for photodynamic therapy (PDT). The photodynamic efficiency of these carboxyfullerenes depends mainly on the cage size, C60 versus C70, and to a lesser extent on the adduct numbers. In particular, malonic acid modified C70 fullerenes are more efficient than their C60 counterparts as photosensitizers, and the mechanism of cell death induced by C70-carboxyfullerene under light irradiation is investigated in detail. The results indicate that cell death occurs via necrosis accompanied by membrane blebbing, which is a unique phenomenon for photosensitizer-induced cell death. Since C70-carboxyfullerene displays an efficient PDT property and negligible dark cytotoxicity, it is promising for use in PDT applications, especially in vascular capillary diseases usually occurring under the surface.