Virus specific cell-mediated immunity may play a role in controlling reactivated human herpesvirus 6B in patients under measles induced immunosuppression.
Virus specific cell-mediated immunity may play a role in controlling reactivated human herpesvirus 6B in patients under measles induced immunosuppression.
复制标题
病毒特异性细胞介导的免疫可能在控制麻疹诱导的免疫抑制患者中重新激活的人类疱疹病毒 6B 方面发挥作用。
DOI：
10.1002/jmv.23862
复制
发表时间：
2014
影响因子：
12.7
通讯作者：
Asano Y.
中科院分区：
文献类型：
--
作者：
Kumagai T;Yoshikawa T;Shiraki K;Yoshida M;Nakayama T;Ihira M;Asano Y.
为了更好地了解再激活的HHV 6B的细胞免疫应答，对22名急性麻疹幼儿和婴儿、19名流感患者和9名健康对照者的3个连续标本进行了人类疱疹病毒6B （HHV 6B）抗原的淋巴增生性反应的测量。22例麻疹患者中有18例外周血单个核细胞（PBMCs）检测到HHV 6B DNA，但在流感患者和健康人群中未检测到。与器官移植患者相比，在麻疹患者中发现了一种新的HHV 6B再激活谱，其免疫抑制形式较轻。通过检测麻疹患者外周血中HHV 6B DNA来评估HHV 6B特异性淋巴细胞增殖活性随着HHV 6B的再激活而相应增加，但从流感患者或健康受试者获得的系列标本中对HHV 6B或DNA血症的抗体反应均未发生显著变化。在麻疹患者中观察到这种无抗体应答的新型HHV 6B再激活。麻疹患者淋巴细胞增生性反应的动态波动可能反映了HHV - 6B再激活与宿主免疫系统抑制之间的平衡。中国生物医学工程学报，2016,35(6):658 - 665。©2014 Wiley期刊公司
For a better understanding of the cellular immune responses to reactivated HHV 6B the lymphoproliferative response to human herpesvirus 6B (HHV 6B) antigen was measured in three consecutive specimens obtained biweekly from 22 young children and infants suffering from acute measles, and in 19 influenza patients and nine healthy control subjects. HHV 6B DNA in peripheral blood mononuclear cells (PBMCs) was detected in 18 of 22 subjects with measles, but not in the influenza patients or the healthy population. A novel reactivation profile of HHV 6B was found in patients with measles in the milder form of immunosuppression than in patients with organ transplantation. HHV 6B specific lymphoproliferation activities increased correspondingly with reactivation of HHV 6B assessed by detecting HHV 6B DNA in PBMCs in patients with measles, but no significant change in either the antibody response to HHV 6B or DNAemia occurred in serial specimens obtained either from patients with influenza or healthy subjects. This novel form of HHV 6B reactivation without antibody response was observed in patients with measles. The dynamic fluctuations in lymphoproliferative responses in measles may represent the balance between HHV 6B reactivation and its suppression by the host immune system.J. Med. Virol. 86:658–665, 2014.© 2014 Wiley Periodicals, Inc.