Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells.
Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells.
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DOI：
10.1586/1744666x.2015.1043893
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发表时间：
2015
影响因子：
4.4
通讯作者：
Agrawal DK
中科院分区：
文献类型：
--
作者：
Nguyen AH;Berim IG;Agrawal DK
炎症受到一个庞大系统的严格调控，这个系统与先天免疫系统错综复杂地相互关联。表达或信号传导的异常，如先天免疫受体，可产生过度炎症，并且在慢性时，通常促进肿瘤发生。髓样细胞表达的触发受体（TREM）受体家族已被表征为炎症反应放大和信号传导的主要参与者。在许多慢性炎症性疾病和恶性肿瘤中，TREM与疾病的严重程度和进展有关。在这篇文章中，目前的理解TREM功能的癌前病变，恶性和慢性炎症条件进行了严格审查。治疗应用的潜力也进行了讨论。
Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells (TREM) receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, TREM has been implicated in disease severity and progression. In this article, the current understanding of TREM function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.