Preparation of bonelike apatite composite for tissue engineering scaffold
Preparation of bonelike apatite composite for tissue engineering scaffold
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DOI：
10.1016/j.stam.2004.07.003
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发表时间：
2005-01-01
影响因子：
5.5
通讯作者：
Ueda, M
中科院分区：
文献类型：
--
作者：
Maeda, H;Kasuga, T;Ueda, M
采用颗粒沥滤技术结合仿生工艺制备了一种新型的聚乳酸复合骨架-类骨磷灰石（b-HA）复合海绵。海绵具有类似于75%的大孔隙率，具有大尺寸的孔，并显示出机械延展性。人成骨细胞孵育7天后，大量细胞附着在覆盖有b-HA的骨骼表面。骨细胞培养结果表明，复合材料上的b-HA具有良好的生物可吸收性。该海绵有望成为骨组织工程支架材料的理想候选材料之一。(c)2004爱思唯尔有限公司保留所有权利。
A novel sponge composed of a poly (lactic acid) composite skeleton covered with bonelike apatite (b-HA) was produced via a particle-leaching technique combined with a biomimetic processing. The sponge has a large porosity of similar to 75% with large-sized pores and shows mechanical ductility. After incubation of human osteoblasts for 7 days, numerous cells attached to the surface of the skeleton, which was covered with b-HA. One result of the osteoclastic cell culture showed that the b-HA on the composite has excellent bioresorbability. The sponge is expected to be one of the promising candidates for bone tissue engineering scaffolds. (c) 2004 Elsevier Ltd. All rights reserved.