Childhood abuse is associated with structural impairment in the ventrolateral prefrontal cortex and aggressiveness in patients with borderline personality disorder
Childhood abuse is associated with structural impairment in the ventrolateral prefrontal cortex and aggressiveness in patients with borderline personality disorder
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DOI：
10.1016/j.pscychresns.2013.02.002
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发表时间：
2013-07-30
影响因子：
2.3
通讯作者：
Brambilla, Paolo
中科院分区：
文献类型：
--
作者：
Morandotti, Niccolo;Dima, Danai;Brambilla, Paolo
在边缘型人格障碍（BPD）中发现了前额皮质（PFC）区域的体积减少和功能障碍，特别是在有儿童虐待史的患者中。这些异常可能导致情绪失调和攻击性的表达。在这项研究中，我们调查了BPD患者的PFC体积是否减少，以及儿童期虐待史是否与PFC结构变化有关。从18名BPD患者和19名年龄、性别、惯用手和教育程度相匹配的健康个体中获得结构MRI数据，并使用基于体素的形态测量学进行分析。儿童虐待量表被用来引出过去的虐待史，侵略使用Buss-Durkee敌意量表（BDHI）进行评估。与无此危险因素的受试者相比，有儿童期虐待史的BPD受试者的右腹外侧PFC（VLPFC）体积显著减少。此外，在有儿童期虐待史的患者中，右侧VLPFC灰质体积与BDHI总分以及BDHI易怒和消极子量表评分显著相关。我们的研究结果表明，童年虐待的历史可能会导致增加侵略介导的损害的权利VLPFC。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Volume reduction and functional impairment in areas of the prefrontal cortex (PFC) have been found in borderline personality disorder (BPD), particularly in patients with a history of childhood abuse. These abnormalities may contribute to the expression of emotion dysregulation and aggressiveness. In this study we investigated whether the volume of the PFC is reduced in BPD patients and whether a history of childhood abuse would be associated with greater PFC structural changes. Structural MRI data were obtained from 18 BPD patients and 19 healthy individuals matched for age, sex, handedness, and education and were analyzed using voxel based morphometry. The Child Abuse Scale was used to elicit a past history of abuse; aggression was evaluated using the Buss-Durkee Hostility Inventory (BDHI). The volume of the right ventrolateral PFC (VLPFC) was significantly reduced in BPD subjects with a history of childhood abuse compared to those without this risk factor. Additionally, right VLPFC gray matter volume significantly correlated with the BDHI total score and with BDHI irritability and negativism subscale scores in patients with a history of childhood abuse. Our results suggest that a history of childhood abuse may lead to increased aggression mediated by an impairment of the right VLPFC. (C) 2013 Elsevier Ireland Ltd. All rights reserved.