Oral Health Status in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Data from the Zabút Aging Project.
Oral Health Status in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Data from the Zabút Aging Project.
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DOI：
10.3233/jad-200385
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发表时间：
2022
影响因子：
4
通讯作者：
Monastero, Roberto
中科院分区：
文献类型：
--
作者：
Panzarella, Vera;Mauceri, Rodolfo;Baschi, Roberta;Maniscalco, Laura;Campisi, Giuseppina;Monastero, Roberto
阿尔茨海默病(AD)与牙周炎的关系最近得到了不同程度的研究。这项研究旨在评估参加扎布老龄化项目的参与者的口腔健康状况及其与认知障碍的关系。扎布老龄化项目是一项基于社区的队列研究，在意大利西西里岛的一个农村社区进行。病例对照研究包括20名AD患者、20名遗忘性轻度认知障碍患者和20名对照组。该方案包括一项全面的医学和认知行为检查。评价患者的全口评价、龈下菌斑样本的微生物分析(通过RT-PCR分析)和口腔健康相关生活质量(OHR-QOL)。AD患者的龋齿、缺牙和充填牙总分显著高于AMCI(p = 0.009)和对照组(p = 0.001)。此外，AD组DMFT的“M”分量(即牙齿缺失的数量)显著高于非老年组(p <； 0.001)和对照组(p <； 0.001)。泊松回归模型显示，年龄(p <； 0.001)、男性(p = 0.001)和AD(p = 0.001)与DMFT呈正相关。在口腔微生物负荷方面，AD组核梭杆菌的存在显著高于对照组(p = 0.004)，齿密螺旋体的负荷显著高于AD组(p = 0.02)。Ohr-QOL得分在不同的组中没有差异。目前的研究表明，AD与慢性牙周炎有关，慢性牙周炎能够确定由于核梭杆菌的致病性而导致的牙齿丢失。这些数据仍有待在更大的基于人群的队列中得到证实。
The relationship between Alzheimer’s disease (AD) and periodontitis has been recently investigated with heterogenous results. This study aims to evaluate the oral health status and its relationship with cognitive impairment of participants, enrolled in the Zabút Aging Project, a community-based cohort study performed in a rural community in Sicily, Italy. A case-control study (20 subjects with AD, 20 with amnestic mild cognitive impairment [aMCI], and 20 controls) was conducted. The protocol included a comprehensive medical and cognitive-behavioral examination. Full-mouth evaluation, microbial analysis of subgingival plaque samples (by RT-PCR analysis), and oral health-related quality of life (OHR-QoL) were evaluated. The decayed, missing, and filled teeth (DMFT) total score of AD subjects was significantly higher than aMCI (p = 0.009) and controls (p = 0.001). Furthermore, the “M” component of DMFT (i.e., the number of missing teeth) was significantly higher in AD than in aMCI (p < 0.001) and controls (p < 0.001). A Poisson regression model revealed that age (p < 0.001), male gender (p = 0.001), and AD (p = 0.001) were positively correlated with DMFT. Concerning oral microbial load, the presence of Fusobacterium nucleatum was significantly higher in AD than in controls (p = 0.02), and a higher load of Treponema denticola was found in aMCI than with AD (p = 0.004). OHR-QoL scores did not differ among the groups. The current research suggests that AD is associated with chronic periodontitis, which is capable of determining tooth loss due to the pathogenicity of Fusobacterium nucleatum. These data remain to be confirmed in larger population-based cohorts.