Dietary interventions that lower lipoproteins containing apolipoprotein C-III are more effective in whites than in blacks: results of the OmniHeart trial
Dietary interventions that lower lipoproteins containing apolipoprotein C-III are more effective in whites than in blacks: results of the OmniHeart trial
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DOI：
10.3945/ajcn.2009.28532
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发表时间：
2010-10-01
影响因子：
7.1
通讯作者：
Sacks, Frank M.
中科院分区：
文献类型：
--
作者：
Furtado, Jeremy D.;Campos, Hannia;Sacks, Frank M.
背景：黑人的平均甘油三酯和低密度脂蛋白胆固醇浓度低于白人，但冠心病的发病率较高。VLDL和LDL中的载脂蛋白（apo）C-III刺激血管细胞中的动脉粥样硬化过程。在黑人中，载脂蛋白C-Ⅲ的浓度是未知的，对降低甘油三酯和载脂蛋白C-Ⅲ的饮食策略的反应尚未研究目的：我们比较了黑人和白人中载脂蛋白C-Ⅲ的浓度和饮食效应。在一个随机的，3阶段喂养研究[OmniHeart我们测量了89名黑人和73名白人的脂蛋白浓度，这些人都吃了自选的饮食（基线）和3个健康饮食后，强调碳水化合物，不饱和脂肪或蛋白质。参与者有高血压前期或高血压，79%超重或obesity.Results：而消费自选diets，黑人有较低的载脂蛋白C-III的总血浆，极低密度脂蛋白和低密度脂蛋白比白人。不饱和脂肪和蛋白质饮食降低了白人的血浆载脂蛋白C-III（分别为16%和18%）和甘油三酯（分别为12%和21%），但黑人没有，减少了种族差异。最重要的是，黑人在基线和研究饮食后具有较低浓度的致动脉粥样硬化LDL和载脂蛋白C-III（低34-41%，P < 0.02）。载脂蛋白E载脂蛋白B的摩尔比是在黑人高于白人在总血浆和低密度脂蛋白在基线和研究diets.Conclusions后：黑人有较低的浓度的致动脉粥样硬化脂蛋白，含有载脂蛋白C-III比白人时，消费多样化的饮食和衰减的饮食反应甘油三酯和载脂蛋白C-III。饮食努力降低甘油三酯和载脂蛋白C-III可能是更有效的白人比黑人。OmniHeart试验在www.clinicaltrials.gov注册为NCT 00051350。美国临床营养杂志2010;92：714-22。
Background: Blacks have lower average triglyceride and LDL cholesterol concentrations than do whites but higher rates of coronary heart disease. Apolipoprotein (apo) C-III in VLDL and LDL stimulates atherogenie processes in vascular cells. In blacks, the concentration of lipoproteins with apo C-III is unknown, and the response to dietary strategies that lower triglyceride and apo C-III has not been investigatedObjective: We compared the concentration of and dietary effects on apo C-III containing lipoproteins in blacks and whites.Design: In a randomized, 3-period feeding study [OmniHeart (Optimal Macronutrient Intake Trial to Prevent Heart Disease)] we measured lipoprotein concentrations in 89 blacks and 73 whites who consumed self-selected diets (baseline) and after 3 healthful diets emphasizing carbohydrate, unsaturated fat, or protein. Participants had prehypertension or hypertension, and 79% were overweight or obese.Results: While consuming self-selected diets, blacks had lower apo C-III in total plasma, VLDL, and LDL than did whites. Unsaturated fat and protein diets lowered plasma apo C-III (16% and 18%, respectively) and triglyceride (12% and 21%, respectively) in whites but not in blacks, reducing racial differences. Most important, blacks had a lower concentration of atherogenic LDL with apo C-III at baseline and after study diets (34-41% lower, P < 0.02). The molar ratio of apo E to apo B was higher in blacks than in whites in total plasma and LDL at baseline and after the study diets.Conclusions: Blacks have lower concentrations of atherogenic lipoproteins that contain apo C-III than do whites when consuming diverse diets and an attenuated dietary response of triglyceride and apo C-III. Dietary efforts to lower triglyceride and apo C-III may be more effective in whites than in blacks. The OmniHeart Trial was registered at www.clinicaltrials.gov as NCT00051350. Am J Clin Nutr 2010;92:714-22.