BLOOD-BRAIN GLUCOSE TRANSFER - REPRESSION IN CHRONIC HYPERGLYCEMIA
BLOOD-BRAIN GLUCOSE TRANSFER - REPRESSION IN CHRONIC HYPERGLYCEMIA
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DOI：
10.1126/science.7027439
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
CRONE, C
中科院分区：
文献类型：
--
作者：
GJEDDE, A;CRONE, C
血糖升高的糖尿病患者在血糖迅速降至正常水平时可出现低血糖的脑症状。这些症状可能表明葡萄糖从血液到大脑的运输不足。慢性高血糖大鼠血脑屏障的最大葡萄糖转运能力从400亩下降到290亩。当血浆葡萄糖降至正常值时，葡萄糖进入脑的转运率比正常值低20%。葡萄糖运输机制的抑制性变化明显发生在脑内皮细胞中，以响应血浆葡萄糖的增加。
Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 .mu.mol/100 g per min. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20% below normal. Repressive changes of the glucose transport mechanism apparently occur in brain endothelial cells in response to increased plasma glucose.